Comparison of the efficacy of 3% hypertonic saline and 20% mannitol in reducing intracranial pressure in patients with traumatic brain injury

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dc.contributor.authorPrakash, Aen_US
dc.contributor.authorKumar, Ven_US
dc.contributor.authorKumar, Den_US
dc.contributor.authorAli, Men_US
dc.contributor.authorAnsari, MH.en_US
dc.date.accessioned2025-05-12T07:25:29Z
dc.date.available2025-05-12T07:25:29Z
dc.date.issued2024-10
dc.description.abstractBackground: Objective of the study was to compare the effects of 3% hypertonic saline (HTS) solution and 20% mannitol (MTL) solution on intracranial hypertension. Methods: The prospective study subjects consisted of 60 patients with traumatic brain injury admitted to the Department of Neurosurgery, RIMS, Ranchi between March 2020 to February 2023. The subjects fulfilling the inclusion criteria were selected and divided into two groups: group A (n=30): treated with 3% HTS, and group B (n=30): treated with 20% MTL. Results: All the findings were noted on Microsoft excel sheet and data were analyzed using the statistical package for the social sciences (SPSS) 21.0 package. Quantitative data were analyzed using student抯 t-test (paired and unpaired) and categorical data were analyzed by the test of proportion, Chi-square, and Fisher抯 exact test. Conclusions: Both 3% HTS and MTL can effectively reduce intracranial pressure, but 3% HTS has a more sustained effect on intracranial pressure and can effectively increase cerebral perfusion pressure.en_US
dc.identifier.affiliationsDepartment of Neurosurgery, RIMS, Ranchi, Jharkhand, Indiaen_US
dc.identifier.affiliationsDepartment of Neurosurgery, RIMS, Ranchi, Jharkhand, Indiaen_US
dc.identifier.affiliationsDepartment of Neurosurgery, RIMS, Ranchi, Jharkhand, Indiaen_US
dc.identifier.affiliationsDepartment of Neurosurgery, RIMS, Ranchi, Jharkhand, Indiaen_US
dc.identifier.affiliationsDepartment of Neurosurgery, RIMS, Ranchi, Jharkhand, Indiaen_US
dc.identifier.citationPrakash A, Kumar V, Kumar D, Ali M, Ansari MH. . Comparison of the efficacy of 3% hypertonic saline and 20% mannitol in reducing intracranial pressure in patients with traumatic brain injury . International Journal of Research in Medical Sciences. 2024 Oct; 12(10): 3661-3664en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246841
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber10en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.18203/2320-6012.ijrms20242676en_US
dc.subjectTBIen_US
dc.subjectHypertonic salineen_US
dc.subjectMannitolen_US
dc.subjectIntracranial pressureen_US
dc.titleComparison of the efficacy of 3% hypertonic saline and 20% mannitol in reducing intracranial pressure in patients with traumatic brain injuryen_US
dc.typeJournal Articleen_US
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