Low dose oral glucocorticoid therapy in lichen planus: A retrospective cohort study

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dc.contributor.authorKoszorú, Kamillaen_US
dc.contributor.authorKovács, Anikóen_US
dc.contributor.authorL?rincz, Kendeen_US
dc.contributor.authorMedvecz, Mártaen_US
dc.contributor.authorSárdy, Miklósen_US
dc.date.accessioned2023-08-10T07:30:56Z
dc.date.available2023-08-10T07:30:56Z
dc.date.issued2023-08
dc.description.abstractBackground: There are various topical and systemic treatment options for the management of lichen planus. However, it is often difficult to achieve long-term disease control and many of the common therapies may be associated with unwanted side effects. Aims: To evaluate the effectiveness of 8 mg oral methylprednisolone administered daily in lichen planus by the analysis of medical records. Methods: In this retrospective cohort study, we compared the rates of improvement between two groups of patients. The first group received 8 mg oral methylprednisolone daily for at least one month. In the second group, patients with similar parameters to the first group (age, sex, disease manifestation) but without systemic glucocorticoid therapy were included. Fisher’s exact test was used to compare the rates of remission in the two groups. Results: In the daily oral methylprednisolone (n = 24) and no systemic corticosteroids (n = 16) groups, 23 (95.8%) and 6 (37.5%) patients achieved partial or complete remission, respectively. The frequency of improvement was significantly higher in patients who received oral methylprednisolone (P < 0.0001). Limitations: Limitations of this study include its retrospective design and the relatively small sample size. Conclusion: Low dose oral glucocorticoid therapy may be an effective option for the systemic treatment of lichen planus. Based on our results and previous studies, instead of higher doses, longer therapy duration with low doses should be considered.en_US
dc.identifier.affiliationsDepartment of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungaryen_US
dc.identifier.citationKoszorú, Kamillaen_US
dc.identifier.citationKovács, Anikóen_US
dc.identifier.citationL?rincz, Kendeen_US
dc.identifier.citationMedvecz, Mártaen_US
dc.identifier.citationSárdy, Miklós. Low dose oral glucocorticoid therapy in lichen planus: A retrospective cohort study. Indian Journal of Dermatology, Venereology and Leprology. 2023 Aug; 89(4): 568-571en_US
dc.identifier.issn0973-3922
dc.identifier.issn0378-6323
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223161
dc.languageenen_US
dc.publisherScientific Scholaren_US
dc.relation.issuenumber4en_US
dc.relation.volume89en_US
dc.source.urihttps://doi.org/10.25259/IJDVL_1111_2021en_US
dc.subjectLichen planusen_US
dc.subjectoral lichen planusen_US
dc.subjectsystemic treatmenten_US
dc.subjectglucocorticoidsen_US
dc.subjectcorticosteroidsen_US
dc.titleLow dose oral glucocorticoid therapy in lichen planus: A retrospective cohort studyen_US
dc.typeJournal Articleen_US
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