Dietary grapes (Vitis vinifera) feeding attenuates ethanol-induced oxidative stress in blood and modulates immune functions in mice.

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dc.contributor.authorMukherjee, Sukhes
dc.contributor.authorDas, Subir Kumar
dc.contributor.authorVasudevan, D M
dc.date.accessioned2012-12-04T04:18:01Z
dc.date.available2012-12-04T04:18:01Z
dc.date.issued2012-10
dc.description.abstractEthanol metabolism is known to induce overwhelming production of reactive oxygen species (ROS) and also to cause associated immune dysfunction. Several interventional agents of plant origin, in particular fruits and vegetables have been used to counteract these alterations induced by ethanol. In this study, we investigated the efficacy of dietary feeding of skin and flesh of grapes (Vitis vinifera L.) on the alterations in immune and vascular functions in mice with liver abnormalities induced by chronic ethanol consumption. Results revealed that feeding of both grape skin and flesh (2.5 g/kg body wt/day) effectively attenuated the oxidative stress and alterations in immune function and angiogenesis induced by chronic ethanol consumption (1.6 g/kg body wt/day for 12 weeks) in mice. The antioxidant actions of the grape skin and flesh as observed in this study might be attributed to the polyphenols present in the grapes.en_US
dc.identifier.citationMukherjee Sukhes, Das Subir Kumar, Vasudevan D M. Dietary grapes (Vitis vinifera) feeding attenuates ethanol-induced oxidative stress in blood and modulates immune functions in mice. Indian Journal of Biochemistry & Biophysics. 2012 Oct; 49(5): 379-385.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/143560
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/14838en_US
dc.subjectCytokinesen_US
dc.subjectEthanolen_US
dc.subjectGrapeen_US
dc.subjectOxidative Stressen_US
dc.subjectPolyphenolsen_US
dc.subjectVitis vinifera Len_US
dc.subject.meshAnimals
dc.subject.meshCytokines --blood
dc.subject.meshCytokines --immunology
dc.subject.meshEthanol --blood
dc.subject.meshEthanol --immunology
dc.subject.meshImmune System Processes -immunology
dc.subject.meshOxidative Stress --physiology
dc.subject.meshPolyphenols
dc.subject.meshVitis --physiology
dc.subject.otherMice
dc.titleDietary grapes (Vitis vinifera) feeding attenuates ethanol-induced oxidative stress in blood and modulates immune functions in mice.en_US
dc.typeArticleen_US
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