Tryptophan as an endogenous photosensitizer to elicit harmful effects of ultraviolet B.

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dc.contributor.authorBabu, Ven_US
dc.contributor.authorJoshi, P Cen_US
dc.date.accessioned1992-06-01en_US
dc.date.accessioned2009-05-27T09:41:15Z
dc.date.available1992-06-01en_US
dc.date.available2009-05-27T09:41:15Z
dc.date.issued1992-06-01en_US
dc.description.abstractOwing to stratospheric ozone depletion (SOD) the natural flux of ultraviolet B (UVB) radiation (290-320 nm) is likely to increase on the earth surface. In our efforts to identify endogenous chromophores which may absorb significantly in the UVB range and subsequently induce phototoxic reactions, we have observed that tryptophan (Trp) was quite photoreactive under UVB. It enhanced considerably the oxygen-dependent photooxidation of tyrosine (Tyr) to dopachrome, a precursor of melanin. Our data suggest that UVB-sensitized Trp produces singlet oxygen (1O2) and superoxide radicals (O2-.), and these reactive forms of oxygen may contribute to membrane-, cytoplasm- and DNA-damaging effects. In the event of an increasing SOD level, other UVB chromophores may also exhibit similar phototoxic properties to lead to a definitive imbalance between cell life, injury and death.en_US
dc.description.affiliationPhototoxicology Laboratory, Industrial Toxicology Research Centre, Lucknow, India.en_US
dc.identifier.citationBabu V, Joshi PC. Tryptophan as an endogenous photosensitizer to elicit harmful effects of ultraviolet B. Indian Journal of Biochemistry & Biophysics. 1992 Jun; 29(3): 296-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28259
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshDihydroxyphenylalanine --chemistryen_US
dc.subject.meshDose-Response Relationship, Radiationen_US
dc.subject.meshIndolequinonesen_US
dc.subject.meshIndolesen_US
dc.subject.meshMonophenol Monooxygenase --radiation effectsen_US
dc.subject.meshOxygenen_US
dc.subject.meshPhotochemistryen_US
dc.subject.meshQuinonesen_US
dc.subject.meshRadiation-Sensitizing Agentsen_US
dc.subject.meshSinglet Oxygenen_US
dc.subject.meshSuperoxidesen_US
dc.subject.meshTryptophanen_US
dc.subject.meshUltraviolet Raysen_US
dc.titleTryptophan as an endogenous photosensitizer to elicit harmful effects of ultraviolet B.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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