Induction of acute respiratory distress syndrome in rats by lipopolysaccharide and its effect on oxidative stress and antioxidant status in lung.

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dc.contributor.authorSabarirajan, Jayaraja
dc.contributor.authorVijayaraj, Panneerselvam
dc.contributor.authorNachiappan, Vasanthi
dc.date.accessioned2011-11-14T10:13:49Z
dc.date.available2011-11-14T10:13:49Z
dc.date.issued2010-10
dc.description.abstractAcute lung injury (ALI) or its severe form, acute respiratory distress syndrome (ARDS) is an important cause of mortality in the human population. Despite significant advances made, the mortality associated with ALI remains unchanged. The objective of the present study was to evaluate the role of oxidative stress, alveolar antioxidant status and multiple organ injury in ARDS induced by lipopolysaccharide (LPS) in rats. Rats were divided into 4 groups, group I control rats were given saline intraperitoneally, whereas groups II, III and IV (LPS-treated) rats received an intraperitoneal injection of LPS (10 mg/kg body weight) and sacrificed after various time intervals. In LPS-treated rats, we observed increased levels of oxidative products, decreased levels of antioxidants in lung tissues and increased levels of serum marker enzymes, suggesting multiple organ injury. Bronchoalveolar lavage fluid (BALF) neutrophil content and protein concentration in LPS-treated rats were significantly elevated in a time-dependent manner. Histological studies revealed neutrophil influx and diffused alveolar damage in LPS-administered rats. These results clearly suggested that increased oxidant levels led to oxidative stress, antioxidant deficiency attenuating lung inflammation and tissue damage. LPS administration resulted in multiple organ failure, leading to increased mortality.en_US
dc.identifier.citationSabarirajan Jayaraja, Vijayaraj Panneerselvam, Nachiappan Vasanthi. Induction of acute respiratory distress syndrome in rats by lipopolysaccharide and its effect on oxidative stress and antioxidant status in lung. Indian Journal of Biochemistry & Biophysics. 2010 Oct; 47(5): 278-284.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135277
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/10521/1/IJBB%2047%285%29%20278-284.pdfen_US
dc.subjectAcute respiratory distress syndromeen_US
dc.subjectLipopolysaccharideen_US
dc.subjectOxidative stressen_US
dc.subjectAlveolar antioxidantsen_US
dc.subjectMultiple organ failureen_US
dc.subject.meshAnimals
dc.subject.meshAntioxidants --metabolism
dc.subject.meshHumans
dc.subject.meshLipopolysaccharides
dc.subject.meshLung --drug effects
dc.subject.meshLung --metabolism
dc.subject.meshMale
dc.subject.meshOxidative Stress --drug effects
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshRespiratory Distress Syndrome, Adult --chemically induced
dc.subject.meshRespiratory Distress Syndrome, Adult --metabolism
dc.titleInduction of acute respiratory distress syndrome in rats by lipopolysaccharide and its effect on oxidative stress and antioxidant status in lung.en_US
dc.typeArticleen_US
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