Clinicopathological spectrum of anterior mediastinal lesions with special reference to the role of cytology in diagnosis: A cross-sectional study

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dc.contributor.authorMondal, Pen_US
dc.contributor.authorNag, Den_US
dc.contributor.authorSamaddar, Aen_US
dc.contributor.authorMangal, Sen_US
dc.contributor.authorDas, Nen_US
dc.contributor.authorSaha, I.en_US
dc.date.accessioned2023-06-27T06:37:42Z
dc.date.available2023-06-27T06:37:42Z
dc.date.issued2022-06
dc.description.abstractBackground: Anterior mediastinal tumors comprise only 3% of all chest tumours. They are often of diagnostic challenge to both clinicians and histopathologists owing to their wide variety of clinical presentations and diversity in histomorphological appearance respectively. Hence, there is a need for elaborated studies to make the pathologists and clinicians aware of their diversity. Aim and Objectives: The present study was aimed to evaluate the diverse spectrum of clinical presentations and histomorphological appearances of anterior mediastinal lesions. In addition, cytological and radiological interpretations were correlated with histological diagnosis to assess their comparative role in diagnosis. Materials and Methods: It was a descriptive observational cross-sectional study. Patients diagnosed with anterior mediastinal mass on chest computed tomography (CT) scan were included in this study. Demographic details including clinical presentations and radiological interpretations were recorded. Patients underwent both CT guided Fine needle aspiration cytology (FNAC) and needle core/excisional biopsy. Histological diagnosis was correlated with radiological and cytological interpretations. Results: Of 659 patients presented with chest tumours, 19 were detected as having anterior mediastinal mass on chest CT scan indicating the prevalence of 2.88%. The most common presenting symptom was respiratory distress (73.68%), followed by chest pain (36.84%), superior vena cava syndrome (26.32%) and Myasthenic features (5.26%). About 50% of malignant tumours occurred at the 2nd decade of life. Thymic epithelial neoplasms comprise the major tumour type in this study (52.63%) followed by germ cell tumors (15.79%) and lymphomas (10.53%). Cytology was found to be more effective compared to radiology in diagnosis. Conclusion: Anterior mediastinal tumors are extremely heterogeneous in clinical presentation and histomorphological appearance. CT-guided FNAC can play an important role in their diagnosis along with radiology and histology.en_US
dc.identifier.affiliationsDepartment of Pathology, Rampurhat Government Medical College and Hospital, Rampurhat, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Medical College and Hospital, Kolkata, West Bengal, Indiaen_US
dc.identifier.citationMondal P, Nag D, Samaddar A, Mangal S, Das N, Saha I.. Clinicopathological spectrum of anterior mediastinal lesions with special reference to the role of cytology in diagnosis: A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology. 2022 Jun; 12(6): 880-885en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/217601
dc.languageenen_US
dc.publisherMrs Dipika Charan of MedScience (India) Publicationsen_US
dc.relation.issuenumber6en_US
dc.relation.volume12en_US
dc.source.urihttps://dx.doi.org/10.5455/njppp.2022.12.11414202102122021en_US
dc.subjectAnterior Mediastinumen_US
dc.subjectMediastinal Massen_US
dc.subjectHistomorphological Spectrumen_US
dc.subjectCytologyen_US
dc.titleClinicopathological spectrum of anterior mediastinal lesions with special reference to the role of cytology in diagnosis: A cross-sectional studyen_US
dc.typeJournal Articleen_US
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