Loss of chromosome Y in acute lymphoblastic leukemia: Age related or neoplastic phenomenon.

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dc.contributor.authorGupta, Anurag
dc.contributor.authorParihar, Mayur
dc.contributor.authorRemani, Arun S
dc.contributor.authorMishra, Deepak Kumar
dc.date.accessioned2015-02-16T05:26:45Z
dc.date.available2015-02-16T05:26:45Z
dc.date.issued2014-07
dc.description.abstractLoss of chromosome Y (LOY) in the bone marrow has long been considered as an age-related phenomenon with an incidence of more than 25% in males beyond the age of 80 years. Though reported as an acquired abnormality in myeloid neoplasms, it has rarely been described in B-lymphoblastic leukemia which primarily is a disease of the young. We describe here in three cases of pediatric B-lymphoblastic leukemia with LOY. Conventional cytogenetic studies and fluorescence in situ hybridization studies using centromeric probes for chromosome X and Y on peripheral blood samples ruled out constitutional LOY in all the three cases favoring it to be a neoplastic phenomenon.en_US
dc.identifier.citationGupta Anurag, Parihar Mayur, Remani Arun S, Mishra Arun S. Loss of chromosome Y in acute lymphoblastic leukemia: Age related or neoplastic phenomenon. Indian Journal of Pathology & Microbiology. 2014 Jul-sept 57 (3): 431-434.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/156078
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2014;volume=57;issue=3;spage=431;epage=434;aulast=Guptaen_US
dc.subjectAcquired abnormalityen_US
dc.subjectB-lymphoblastic leukemiaen_US
dc.subjectloss of chromosome Yen_US
dc.subjectpediatricen_US
dc.titleLoss of chromosome Y in acute lymphoblastic leukemia: Age related or neoplastic phenomenon.en_US
dc.typeArticleen_US
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