A Comparative Study for Efficacy and Tolerability of Satranidazole Plus Ofloxacin Versus Ornidazole Plus Ofloxacin in Periodontal Infections.
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Date
2013-12
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Abstract
Periodontal infections and related
conditions like Chronic Gingivitis, Chronic Periodontitis,
Pericoronitis, Peridontal & Periapical Abscess are common
clinical problems, but sometimes Gingivitis and Periodontitis
can be acute also. These all are generally treated by scaling
and root planning, but studies have reported that despite
conventional periodontal therapy certain sites continue to
show periodontal tissue destruction. These periodontal
infections can be controlled by antibiotics which are effective
against Gram-negative aerobic and anaerobic bacteria and
has good penetration in periodontal tissues. Objective: The
purpose of the present study was to compare the efficacy
and tolerability of a fixed dose combination of Satranidazole
(300 mg) plus Ofloxacin (200 mg) versus fixed dose
combination of Ornidazole (500 mg) plus Ofloxacin (200
mg) for the treatment of periodontal infections. Methods :
One hundred and twelve adult patients (59 females and 53
males) with moderate to advanced periodontitis were
enrolled and given fixed dose combination of Satranidazole
(300 mg) plus Ofloxacin (200 mg) or Ornidazole (500 mg)
plus Ofloxacin (200 mg) orally two times daily. Clinical
assessment like Gingival Index, Periodontal Index, Mobility
Index and VAS Score were done before and after the
treatment. Clinical evaluation was performed on 3rd and
5th day after treatment. Results : At the baseline the values
for Gingival Index, Periodontal Index, Mobility Index and
VAS Score were comparable in both the groups. Both the
treatment group have shown attenuation of Gingival Index,
Periodontal Index, Mobility Index and VAS Score. However,
treatment with Satranidazole plus Ofloxacin showed
significantly (p< 0.05) better improvement in all clinical
parameters compared to Ornidazole plus Ofloxacin
treatment. Treatment with Satranidazole plus Ofloxacin was
well tolerated and no serious adverse event was observed.
6 patients (15%) with Ornidazole plus Ofloxacin have
shown side effects, which resulted in discontinuation of
therapy. These side effects include allergy, nausea, vomiting
& acidity. Conclusion : This study concludes that efficacy
and tolerability of fixed dose combination of Satranidazole
(300 mg) plus Ofloxacin (200 mg) is better than fixed dose
combination of Ornidazole (500 mg) plus Ofloxacin (200
mg) in treatment of periodontal infections.
Description
Keywords
Periodontal infection, satranidazole plus ofloxacin, gingival index
Citation
Mundade Yogesh, Srivastava Ambrish, Somani Rahul, Kulkarni Kamlakar. A Comparative Study for Efficacy and Tolerability of Satranidazole Plus Ofloxacin Versus Ornidazole Plus Ofloxacin in Periodontal Infections. Indian Medical Gazette. 2013 Dec ; 147 (12): 448-453.