Profile of hepatitis B e antigen-negative chronic hepatitis B.

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dc.contributor.authorAmarapurkar, D Nen_US
dc.contributor.authorBaijal, Ren_US
dc.contributor.authorKulshrestha, P Pen_US
dc.contributor.authorAgal, Sen_US
dc.contributor.authorChakraborty, M Ren_US
dc.contributor.authorPramanik, S Sen_US
dc.date.accessioned2002-05-18en_US
dc.date.accessioned2009-05-29T03:41:05Z
dc.date.available2002-05-18en_US
dc.date.available2009-05-29T03:41:05Z
dc.date.issued2002-05-18en_US
dc.description.abstractBACKGROUND: Although chronic hepatitis B occurs in hepatitis B e antigen (HBeAg)-negative patients, its prevalence and clinical significance are not known. AIM: To determine the prevalence and profile of HBeAg-negative chronic hepatitis B virus (HBV) infection. METHODS: A retrospective analysis of 363 consecutive patients (mean age 36 y; 288 men) with chronic HBV infection was performed. All patients were HBsAg-positive. Tests for liver profile, HBeAg and anti-HBe antibody were performed in all patients. Serum HBV DNA was tested using branched DNA assay in 245 patients. The patients were classified into three groups: no cirrhosis with normal ALT levels, no cirrhosis with elevated ALT levels, and clinical or histological evidence of cirrhosis. RESULTS: Of 363 patients, 141 (39%) were HBeAg-positive and 222 (61%) HBeAg-negative. Of HBeAg-negative patients, 120 (54%) had normal ALT, 45 (20%) had elevated ALT and 57 (26%) had evidence of cirrhosis; corresponding figures in the HBeAg-positive patients were 40 (28%), 66 (47%) and 35 (25%). HBV DNA was positive in 53 of 131 (40%) HBeAg-negative patients tested; of these 53 patients, 9 (17%) had normal ALT, 20 (38%) had elevated ALT and 24 (45%) had cirrhosis. Thus, 72% of HBeAg-positive and 46% of HBeAg-negative patients had elevated ALT and/or cirrhosis. Among the latter group, 83% of HBV DNA-positive patients had elevated ALT and/or cirrhosis. Overall, 18% of HBsAg-positive patients had HBeAg-negative, HBV DNA-positive liver disease. CONCLUSION: HBeAg-negative chronic hepatitis B is not an uncommon and benign entity and chronic liver disease develops in a significant proportion of such patients.en_US
dc.description.affiliationDepartment of Gastroenterology, Bombay Hospital, Mumbai. deepakn@bom3.vsnl.net.inen_US
dc.identifier.citationAmarapurkar DN, Baijal R, Kulshrestha PP, Agal S, Chakraborty MR, Pramanik SS. Profile of hepatitis B e antigen-negative chronic hepatitis B. Indian Journal of Gastroenterology. 2002 May-Jun; 21(3): 99-101en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/65629
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAlanine Transaminase --blooden_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B Surface Antigens --blooden_US
dc.subject.meshHepatitis B e Antigens --blooden_US
dc.subject.meshHepatitis B virus --geneticsen_US
dc.subject.meshHepatitis B, Chronic --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshLiver --pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRetrospective Studiesen_US
dc.titleProfile of hepatitis B e antigen-negative chronic hepatitis B.en_US
dc.typeJournal Articleen_US
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