Increased cortical excitability with longer duration of Parkinson's disease as evaluated by transcranial magnetic stimulation.

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dc.contributor.authorBhatia, Men_US
dc.contributor.authorJohri, Sen_US
dc.contributor.authorBehari, Men_US
dc.date.accessioned2003-03-17en_US
dc.date.accessioned2009-06-03T12:32:17Z
dc.date.available2003-03-17en_US
dc.date.available2009-06-03T12:32:17Z
dc.date.issued2003-03-17en_US
dc.description.abstractTranscranial Magnetic Stimulation (TMS) was used to evaluate the cortical excitability and central motor pathways in Parkinson's disease (PD) and correlate with severity and duration of disease. 19 cases of PD and 13 controls were enrolled. The threshold intensity (TI), cortical latency (CL), central conduction time (CCT), motor evoked potential amplitude (MEP) obtained with TMS were correlated with Hoehn and Yahr and duration of disease. The threshold intensity (TI) was significantly lower in patients of PD than controls. The TI in patients with PD was 53.16-/+8.4% patients and 67.1-/+21.6% in controls (p<0.05). This strongly correlated with duration of disease, TI being lower in patients with disease duration more than 5 years. There was no difference in the other TMS parameters - CL, CCT, MEP between patients and controls. Our study revealed increased excitability in PD which was related to longer duration of disease.en_US
dc.description.affiliationDepartment of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110 029, India. manvirbhatia@hotmail.comen_US
dc.identifier.citationBhatia M, Johri S, Behari M. Increased cortical excitability with longer duration of Parkinson's disease as evaluated by transcranial magnetic stimulation. Neurology India. 2003 Mar; 51(1): 13-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/121620
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshAgeden_US
dc.subject.meshCerebral Cortex --physiopathologyen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshParkinson Disease --diagnosisen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshTranscranial Magnetic Stimulationen_US
dc.titleIncreased cortical excitability with longer duration of Parkinson's disease as evaluated by transcranial magnetic stimulation.en_US
dc.typeClinical Trialen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
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