Association Of GC Phenotypes With Pre-eclampsia-Possibility For A Causal Role.
| dc.contributor.author | Veena, T P | |
| dc.contributor.author | Vishnupriya, S | |
| dc.contributor.author | Padma, T | |
| dc.date.accessioned | 2015-07-15T12:01:43Z | |
| dc.date.available | 2015-07-15T12:01:43Z | |
| dc.date.issued | 1997-04 | |
| dc.description.abstract | Pre-eclampsia is a hypertensive disorder of pregnancy and has been reported to be associated with altered vitamin D levels. GC being a vitamin D binding protein, may be playing a functional role in the pathophysiology of the disease. The present investigation conducted on 100 pre-eclamptic and hypertensive controls with a corresponding decrease in GC 1-1 phenotype as compared to normotensive controls. There was no difference in the frequency of GC 2-2 phenotype between eclamptic women and controls. A similar trent was observed in moderate and severe cases of pre-eclampsia and in multigravid women with recurrence of pre-eclampsia. Relative risk estimates revealed an increased risk for moderate and severe types of pre-eclampsia when their phenotypes were of GC 2-1. The increase in heterozygote frequency of GC in pre-eclampsia and hypertensive controls as compared to normotensive controls, indicates the risk of GC 2-1 phenotype which could be due to a direct physiological effect against the disease through increased physiological versatility where the two alleles of GC may vary functionally. It may be possible that the binding capacity of GC alleles 1 and 2 with vitamin D may be varying on similar lines as haptoglobin with haemoglobin. The altered levels of vitamin D as reported by many authors and the increased risk of GC 2-1 phenotype observed in the present study indicate a possibility for a causal relationship of this phenotype with the disease probably With a functional role. | en_US |
| dc.identifier.citation | Veena T P, Vishnupriya S, Padma T. Association Of GC Phenotypes With Pre-eclampsia-Possibility For A Causal Role. Indian Journal of Human Genetics. 1997 Apr; 3(2): 101-105. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/159813 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.ijhg.com/article.asp?issn=0971-6866;year=1997;volume=3;issue=2;spage=101;epage=105;aulast=Veena;type=2 | en_US |
| dc.subject | GC phenotype | en_US |
| dc.subject | Pre-eclampsia | en_US |
| dc.subject | Hypertension | en_US |
| dc.subject | Relative risk | en_US |
| dc.title | Association Of GC Phenotypes With Pre-eclampsia-Possibility For A Causal Role. | en_US |
| dc.type | Article | en_US |