Bispectral index in assessment of 3% and 4.5% desflurane in 50% N2O for caesarean section.

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dc.contributor.authorIttichaikulthol, Wichaien_US
dc.contributor.authorSriswasdi, Suriraten_US
dc.contributor.authorPrachanpanich, Naruemolen_US
dc.contributor.authorWatcharotayangul, Jittiyaen_US
dc.contributor.authorSeangrung, Rattapholen_US
dc.contributor.authorSithamwilai, Wannipaen_US
dc.date.accessioned2009-05-27T21:07:00Z
dc.date.available2009-05-27T21:07:00Z
dc.date.issued2007-08-12en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractBACKGROUND: To prevent awareness and uterine atony among parturients during general anesthesia for caesarean section, volatile anesthetic agents have been limited to 0.5 MAC in 50% N2O. This technique appeared to be inadequate to produce BIS values less than 60 in isoflurane and sevoflurane. OBJECTIVE: To assess BIS value during general anesthesia with 3% and 4.5% desflurane in 50% N2O before delivery. MATERIAL AND METHOD: The parturients were blinded and randomized in opaque envelopes to one of the two study groups. Seventy-two elective caesarean section ASA I - II parturients were induced and intubated with thiopental 4 mg/kg, succinylcholine 1.5 mg/kg and were received either 3% or 4.5% desflurane in 50% N2O to maintain general anesthesia. Both groups received rocuronium 0.6 mg/kg for muscle relaxation. Morphine 0.1 mg/kg and midazolam 0.06 mg/kg were administered after delivery. RESULTS: There were no differences in demographic data in both groups. The incidences of patients with a satisfactory BIS score (< 60) in the 4.5% desflurane group was 81% that was significantly more than 42% in the 3% desflurane group (p < 0.000). Mean BIS values at neonatal delivery were 62 +/- 8 in the 3% desflurane group, versus 49 +/- 12 in the 4.5% desflurane group. Indices of maternal and neonatal outcome were similar between the two groups. CONCLUSION: General anesthesia for caesarean section with 4.5% desflurane in 50% N2O maintained BIS < 60 more significantly than 3% of desflurane in 50% N2O without maternal and neonatal adverse effects in healthy paturients.en_US
dc.description.affiliationDepartment of Anesthesiology, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.en_US
dc.identifier.citationIttichaikulthol W, Sriswasdi S, Prachanpanich N, Watcharotayangul J, Seangrung R, Sithamwilai W. Bispectral index in assessment of 3% and 4.5% desflurane in 50% N2O for caesarean section. Journal of the Medical Association of Thailand. 2007 Aug; 90(8): 1546-50en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/44222
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshAnesthesia, Obstetricalen_US
dc.subject.meshAnesthetics, Inhalationen_US
dc.subject.meshCesarean Sectionen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshElectroencephalographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoflurane --analogs & derivativesen_US
dc.subject.meshMonitoring, Intraoperativeen_US
dc.subject.meshNitrous Oxideen_US
dc.subject.meshPregnancyen_US
dc.titleBispectral index in assessment of 3% and 4.5% desflurane in 50% N2O for caesarean section.en_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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