Epidemic of fever of unknown origin in rural Thailand, caused by influenza A (H1N1) and dengue fever.

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dc.contributor.authorSilarug, Nen_US
dc.contributor.authorFoy, H Men_US
dc.contributor.authorKupradinon, Sen_US
dc.contributor.authorRojanasuphot, Sen_US
dc.contributor.authorNisalak, Aen_US
dc.contributor.authorPongsuwant, Yen_US
dc.date.accessioned2009-05-27T15:01:44Z
dc.date.available2009-05-27T15:01:44Z
dc.date.issued1990-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractIn the late summer (rainy season) of 1987, a sharp outbreak of fever of unknown origin (FUO) in rural southern Thailand was investigated by a field epidemiology team. In a random survey of households, 40 percent of the children and 20 percent of adults were reported to have had febrile illnesses within the last month. There was at least one death, possibly from Reye's syndrome. Testing 34 pairs of acute and convalescent sera showed significant HI antibody titer rises to influenza A (Taiwan/(H1N1) (9 cases) and dengue virus (12 cases). Testing 79 single sera with the antibody capture ELISA test for dengue, revealed that 23 percent had high titers in the IgM serum fraction suggesting recent infection. There were also six antibody titer rises to coxsackie B viruses, three from well controls. Dengue has previously been observed as a cause of FUO in rural areas in the tropics, but finding a combined epidemic of dengue and influenza was unexpected. With cooperative villagers, adequate personnel and laboratory support, especially the antigen capture ELISA test for dengue infections, it is feasible to successfully investigate disease outbreaks with serologic methods in remote villages.en_US
dc.description.affiliationDivision of Epidemiology, Ministry of Public Health, Bangkok, Thailand.en_US
dc.identifier.citationSilarug N, Foy HM, Kupradinon S, Rojanasuphot S, Nisalak A, Pongsuwant Y. Epidemic of fever of unknown origin in rural Thailand, caused by influenza A (H1N1) and dengue fever. The Southeast Asian Journal of Tropical Medicine and Public Health. 1990 Mar; 21(1): 61-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/31727
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshChikungunya virusen_US
dc.subject.meshCoxsackievirus Infections --diagnosisen_US
dc.subject.meshDengue --diagnosisen_US
dc.subject.meshDisease Outbreaksen_US
dc.subject.meshEnterovirus B, Humanen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshFever of Unknown Origin --epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza A Virus, H1N1 Subtypeen_US
dc.subject.meshInfluenza A virusen_US
dc.subject.meshInfluenza, Human --diagnosisen_US
dc.subject.meshMaleen_US
dc.subject.meshRural Populationen_US
dc.subject.meshThailand --epidemiologyen_US
dc.subject.meshTogaviridae Infections --diagnosisen_US
dc.titleEpidemic of fever of unknown origin in rural Thailand, caused by influenza A (H1N1) and dengue fever.en_US
dc.typeJournal Articleen_US
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