Sicca symptoms in Thai patients with rheumatoid arthritis, systemic lupus erythematosus and scleroderma: a comparison with age-matched controls and correlation with disease variables.

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dc.contributor.authorWangkaew, Suparapornen_US
dc.contributor.authorKasitanon, Nuntanaen_US
dc.contributor.authorSivasomboon, Chateen_US
dc.contributor.authorWichainun, Ramjaien_US
dc.contributor.authorSukitawut, Warapornen_US
dc.contributor.authorLouthrenoo, Worawiten_US
dc.date.accessioned2009-05-27T17:26:26Z
dc.date.available2009-05-27T17:26:26Z
dc.date.issued2006-12-14en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractThis study was performed to determine the prevalence of ocular and oral sicca symptoms in Thai patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and scleroderma (Scl). The ocular symptoms and sign (the Schirmer's 1 test) and the oral sicca symptoms and sign (the Saxon's test) in each of 50 RA, SLE and Scl patients were compared with their age-matched controls. The correlation between the presence of sicca symptoms and signs with their clinical activity was also determined. Ocular sicca symptoms were found more common in patients with RA (38% vs 18%, p < 0.05), SLE (36% vs 14%, p < 0.05) and Scl (54% vs 16%, p < 0.01), and oral sicca symptoms were found more common in SLE (22% vs 0%, p < 0.01), and Scl (16% vs 4%, p < 0.05) than their controls. However, only RA patients had a significantly higher proportion of positive Schimer-1 test compared with their controls (p < 0.01). There was no strong correlation between sicca symptoms or signs and other clinical or laboratory variables (age, disease duration, disease activity, disease severity, and antibody to Ro and La antigens) in these three groups. In conclusion, sicca symptoms were seen significantly more common in Thai patients with connective tissue diseases, but the symptoms did not show a good correlation with the clinical and laboratory variables.en_US
dc.description.affiliationDivision of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Thailand.en_US
dc.identifier.citationWangkaew S, Kasitanon N, Sivasomboon C, Wichainun R, Sukitawut W, Louthrenoo W. Sicca symptoms in Thai patients with rheumatoid arthritis, systemic lupus erythematosus and scleroderma: a comparison with age-matched controls and correlation with disease variables. Asian Pacific Journal of Allergy and Immunology. 2006 Dec; 24(4): 213-21en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37197
dc.language.isoengen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshArthritis, Rheumatoid --complicationsen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshEye --pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshLupus Erythematosus, Systemic --complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMouth --pathologyen_US
dc.subject.meshScleroderma, Systemic --complicationsen_US
dc.subject.meshSjogren's Syndrome --complicationsen_US
dc.subject.meshThailanden_US
dc.titleSicca symptoms in Thai patients with rheumatoid arthritis, systemic lupus erythematosus and scleroderma: a comparison with age-matched controls and correlation with disease variables.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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