Induction of oxidative stress by restraint stress and corticosterone treatments in rats.

Simple item page
dc.contributor.authorZafir, Ayeshaen_US
dc.contributor.authorBanu, Naheeden_US
dc.date.accessioned2009-02-21en_US
dc.date.accessioned2009-05-27T09:52:47Z
dc.date.available2009-02-21en_US
dc.date.available2009-05-27T09:52:47Z
dc.date.issued2009-02-21en_US
dc.description.abstractChronic exposure to psychological stress in humans and restraint stress in experimental animals results in increased oxidative stress and resultant tissue damage. To study the contribution of stress hormones towards stress-induced oxidative processes in the brain, we investigated the response of important free-radical scavenging enzymes toward chronic administration of two doses of corticosterone (low dose: 10 mg/kg/day, high dose: 40 mg/kg/day) in rodents. After a 21-day experimental period, a significant decline in both superoxide dismutase and catalase was observed in both stressed and stress hormone-treated animals. The brain levels of glutathione as well as the activities of glutathione-S-transferase and glutathione reductase were also significantly decreased, while lipid peroxidation levels were significantly increased in comparison to controls. A direct pro-oxidant effect of stress hormones in the brain during physical and psychological stress was observed, indicating important implications for oxidative stress as a major pathological mechanism during chronic stress and a consequent target option for anti-stress therapeutic interventions.en_US
dc.description.affiliationDepartment of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002 (UP) India.en_US
dc.identifier.citationZafir A, Banu N. Induction of oxidative stress by restraint stress and corticosterone treatments in rats. Indian Journal of Biochemistry & Biophysics. 2009 Feb; 46(1): 53-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28834
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnalysis of Variance
dc.subject.meshAnimals
dc.subject.meshBlood Glucose --metabolism
dc.subject.meshBrain --drug effects
dc.subject.meshBrain --enzymology
dc.subject.meshBrain --metabolism
dc.subject.meshCatalase --metabolism
dc.subject.meshCorticosterone --administration & dosage
dc.subject.meshFree Radical Scavengers --metabolism
dc.subject.meshGlutathione --metabolism
dc.subject.meshGlutathione Reductase --metabolism
dc.subject.meshGlutathione Transferase --metabolism
dc.subject.meshLipid Peroxidation --drug effects
dc.subject.meshOxidants --administration & dosage
dc.subject.meshOxidative Stress --drug effects
dc.subject.meshOxidative Stress --physiology
dc.subject.meshRandom Allocation
dc.subject.meshRats
dc.subject.meshRestraint, Physical
dc.subject.meshStress, Psychological
dc.subject.meshSuperoxide Dismutase --metabolism
dc.titleInduction of oxidative stress by restraint stress and corticosterone treatments in rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Biochemistry & Biophysics