Pancreatic islet transplantation: utility of ductular obstruction and exocrine atrophy model?

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dc.contributor.authorVerma, Aen_US
dc.contributor.authorDinda, Aen_US
dc.contributor.authorSarkar, Cen_US
dc.contributor.authorFotedar, Ren_US
dc.contributor.authorDhawan, I Ken_US
dc.contributor.authorSharma, L Ken_US
dc.contributor.authorKhetarpal, Ken_US
dc.contributor.authorFotedar, Aen_US
dc.contributor.authorSrikanta, Sen_US
dc.contributor.authorKochupillai, Nen_US
dc.date.accessioned1990-07-01en_US
dc.date.accessioned2009-06-04T04:37:40Z
dc.date.available1990-07-01en_US
dc.date.available2009-06-04T04:37:40Z
dc.date.issued1990-07-01en_US
dc.description.abstractIntroduction of 'silent' exocrine atrophy (and endocrine 'enrichment') in pancreatic grafts following ductular blockade may have a role in human diabetes by circumventing currently elusive islet isolation/purification protocols. To explore this potential, pancreatic isografts were performed in 12 pairs of inbred Wistar NIN rats. Donor pancreatectomy was performed after distal clamping and canulation of common bile duct and injection of 0.5 ml. polyacrylamide gel (blocked n = 7) or normal saline (un-blocked n = 5) respectively. One to 2 m.m. fragments of the resulting mildly distended pancreases were transplanted in to 2 sites (renal capsule and iliac fossa subcutaneously) of cach recipient. Post-operative biopsies of the transplanted grafts (unilateral nephrectomy and iliac fossa biopsies) revealed macroscopic and microscopic evidence of necrotizing pancreatitis in both the groups at both the sites (histiocytic and giant cell infiltration, fat necrosis and focal calcification with destruction of exocrine and endocrine cells) as early as 1 and 3 weeks. Possible detrimental factors include: volume and pressure of ductal injection, graft sites (confined spaces), post-operative wound infection and bio-compatibility of the material used for ductular blockade.en_US
dc.description.affiliationIslet cell Transplantation Study Group, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationVerma A, Dinda A, Sarkar C, Fotedar R, Dhawan IK, Sharma LK, Khetarpal K, Fotedar A, Srikanta S, Kochupillai N. Pancreatic islet transplantation: utility of ductular obstruction and exocrine atrophy model? Tropical Gastroenterology. 1990 Jul-Sep; 11(3): 148-51en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/125045
dc.language.isoengen_US
dc.source.urihttps://www.tropicalgastro.comen_US
dc.subject.meshAcrylic Resinsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCommon Bile Ducten_US
dc.subject.meshGelsen_US
dc.subject.meshIslets of Langerhans Transplantation --methodsen_US
dc.subject.meshPancreatic Ductsen_US
dc.subject.meshProstheses and Implantsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.titlePancreatic islet transplantation: utility of ductular obstruction and exocrine atrophy model?en_US
dc.typeJournal Articleen_US
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