Risk Prediction of Bladder Carcinomas in Atypical Urine Specimens by Redefining Diagnostic Cytomorphological Criteria

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dc.contributor.authorShukla, Pen_US
dc.contributor.authorOjha, T.en_US
dc.date.accessioned2025-06-18T10:11:58Z
dc.date.available2025-06-18T10:11:58Z
dc.date.issued2025-04
dc.description.abstractIntroduction: Urine cytology in bladder tumors is challenging due to the lack of definite cytomorphological criteria in categorizing atypical cases. The study aims to re?evaluate atypia in the light of three definitive cytological parameters (high N/C ratio, hyperchromasia, and irregular nuclear contours) and correlate with the follow?up histopathology and cytopathology with an attempt to redefine the morphological features that would aid in distinguishing reactive atypia from malignancy. Materials and Methods: A retrospective analysis of 56 atypical urine specimens was performed considering three definitive cytomorphological parameters. All cases were classified into the following categories: atypical urothelial cells (AUCs)?favor reactive, AUCs?not otherwise specified (AUC?NOS), AUCs?favor neoplastic (AUC?FN), urothelial carcinoma (UC), and negative for malignancy (NEM). The cases reviewed were correlated with follow?up histopathology and cystoscopy. The sensitivity and specificity of urine cytology were then assessed. Results: Out of 56 cases, 20 cases (35.7%) were positive on urine cytology (AUC?FN/UC), and amongst them, 16 cases (80%) showed positive follow?up. Among the AUC?NOS category, 71% of the cases showed positive follow?up. The sensitivity and specificity of urine cytology in atypical cases were 89.8% and 87.5%, respectively. Conclusions: Urine cytology can be potentially useful in predicting the risk of bladder carcinomas when definite cytomorphological features are analyzed stringently. Moreover, urine cytology in conjunction with cystoscopy can increase the detection rate of malignancy with greater accuracy.en_US
dc.identifier.affiliationsDepartment of Pathology, Hind Institute of Medical Sciences, Barabanki, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Radiology, Ojha Diagnostic Centre, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.citationShukla P, Ojha T. . Risk Prediction of Bladder Carcinomas in Atypical Urine Specimens by Redefining Diagnostic Cytomorphological Criteria. Acta Medica International. 2025 Apr; 12(1): 1-6en_US
dc.identifier.issn2349-0578
dc.identifier.issn2349-0896
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247990
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.4103/amit.amit_92_24en_US
dc.subjectAtypicalen_US
dc.subjectbladder tumoren_US
dc.subjectcytomorphologicalen_US
dc.subjectdefinitive criteriaen_US
dc.subjecturineen_US
dc.titleRisk Prediction of Bladder Carcinomas in Atypical Urine Specimens by Redefining Diagnostic Cytomorphological Criteriaen_US
dc.typeJournal Articleen_US
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