Lack of efficacy of quinine and artemether against advanced third-stage larvae of Gnathostoma spinigerum in vitro.

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dc.contributor.authorSukontason, Ken_US
dc.contributor.authorKlaolaor, Pen_US
dc.contributor.authorSukontason, Ken_US
dc.contributor.authorPiangjai, Sen_US
dc.contributor.authorMethanitikorn, Ren_US
dc.contributor.authorMorakote, Nen_US
dc.date.accessioned2009-05-27T14:43:33Z
dc.date.available2009-05-27T14:43:33Z
dc.date.issued2000-06-29en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe efficacy of quinine and artemether--the effective blood schizontocide in malarial treatment--has been in vitro tested with the advanced third-stage larvae of Gnathostoma spinigerum. All larvae were collected from freshwater eel (Fluta alba) and exposed to the culture medium, each containing either quinine dihydrochloride or artemether at a final concentration of 20 microg/ml and 0.5 microg/ml, respectively for 21 consecutive days. Larval motility was assessed daily and the topographical changes were assessed using scanning electron microscope after 21-days of drug exposure. All worms moved actively for 21 days of study period and no change in surface ultrastructure was observed. Quinine and artemether at these concentrations have no effect on movement and topographical changes on the advanced third-stage larvae of this parasite.en_US
dc.description.affiliationDepartment of Parasitology, Faculty of Medicine, Chiang Mai University, Thailand. ksukonta@suandok01.medicine.cmu.ac.then_US
dc.identifier.citationSukontason K, Klaolaor P, Sukontason K, Piangjai S, Methanitikorn R, Morakote N. Lack of efficacy of quinine and artemether against advanced third-stage larvae of Gnathostoma spinigerum in vitro. The Southeast Asian Journal of Tropical Medicine and Public Health. 2000 Jun; 31(2): 412-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/30913
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2000_31_2/36-2479.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntinematodal Agents --pharmacologyen_US
dc.subject.meshArtemisininsen_US
dc.subject.meshEels --parasitologyen_US
dc.subject.meshGnathostoma --drug effectsen_US
dc.subject.meshLarva --growth & developmenten_US
dc.subject.meshQuinine --pharmacologyen_US
dc.subject.meshSesquiterpenes --pharmacologyen_US
dc.titleLack of efficacy of quinine and artemether against advanced third-stage larvae of Gnathostoma spinigerum in vitro.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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