Amlodipine in mild and moderate hypertension: initial Indian experience.

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dc.contributor.authorKhokhani, R Cen_US
dc.contributor.authorChopra, Pen_US
dc.contributor.authorKarnik, N Den_US
dc.contributor.authorBajan, K Den_US
dc.contributor.authorAiliani, Ren_US
dc.contributor.authorWaknis, S Sen_US
dc.contributor.authorJoseph, T Aen_US
dc.contributor.authorChawla, K Pen_US
dc.date.accessioned1993-10-01en_US
dc.date.accessioned2009-05-30T23:31:33Z
dc.date.available1993-10-01en_US
dc.date.available2009-05-30T23:31:33Z
dc.date.issued1993-10-01en_US
dc.description.abstractIn an open, non-comparative, variable-dose study, 20 outpatients with mild to moderate essential hypertension were treated with 5-10 mg amlodipine once daily for 4 weeks, after their blood pressures had stabilized on placebo. Amlodipine produced a significant decrease in blood pressure (P < 0.05) from the initial mean of 162/100 mm Hg to 139/85 mm Hg at 4 weeks. 80% of the patients reached the goal diastolic blood pressure of < or = 90 mm Hg with a once-daily dose of 5 mg amlodipine within 2 weeks. The remaining 20% also attained the goal diastolic blood pressure within 4 weeks, with a one-step increase in the dose to 10 mg at 2 weeks. Amlodipine maintained blood pressure reduction throughout the 24-hours dosing interval with a once-daily dose. Notably, no side effects were observed; pulse rate, electrocardiogram, and laboratory parameters were not significantly altered with therapy. Amlodipine in a single daily dose of 5-10 mg is effective and well tolerated in the treatment of patients with mild to moderate hypertension.en_US
dc.description.affiliationMedical Research Division, Pfizer Ltd., Bombay.en_US
dc.identifier.citationKhokhani RC, Chopra P, Karnik ND, Bajan KD, Ailiani R, Waknis SS, Joseph TA, Chawla KP. Amlodipine in mild and moderate hypertension: initial Indian experience. Journal of the Association of Physicians of India. 1993 Oct; 41(10): 662-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/90502
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAmlodipine --therapeutic useen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSingle-Blind Methoden_US
dc.titleAmlodipine in mild and moderate hypertension: initial Indian experience.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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