Anti-C1q antibody as a marker of disease activity in systemic lupus erythematosus.

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dc.contributor.authorKumar, Aen_US
dc.contributor.authorGupta, Ren_US
dc.contributor.authorVarghese, Ten_US
dc.contributor.authorPande, R Men_US
dc.contributor.authorSingal, V Ken_US
dc.contributor.authorGarg, O Pen_US
dc.date.accessioned1999-12-04en_US
dc.date.accessioned2009-05-27T07:05:56Z
dc.date.available1999-12-04en_US
dc.date.available2009-05-27T07:05:56Z
dc.date.issued1999-12-04en_US
dc.description.abstractThe present study was conducted to examine the usefulness of anti-C1q antibody as a marker of disease activity in Indian patients with systemic lupus erythematosus (SLE). We standardized the assay for detection of IgG anti-C1q antibody using ELISA. The normal cut-off level was determined by testing 57 healthy, age and sex matched controls to be 53 units/m1 (mean +/- 2 SD). Patients with SEL (97 females and 13 males) were studied and the following parameters were obtained on all: SLE disease activity index (SLEDAI), anti-C1q, anti-ds DNA and C3. Correlations were tested between these parameters using Spearman's rank correlation coefficients. Anti-C1q was found positive in 66 (60%) patients while anti-ds DNA was found in 78 (71%). The positive predictive values of anti-C1q and anti-ds DNA for lupus nephritis were 59 and 61 per cent respectively. The titres of anti-C1q correlated positively with SLEDAI (P < 0.01) and anti-ds DNA (P < 0.01) and negatively with C3 levels (P < 0.001). No significant correlation was observed between anti-C1q positivity and any particular organ involvement. Similarly, no correlation was found between anti-C1q and proliferative lupus nephritis. Anti-C1q was found positive in 5 of 9 patients with moderate SLEDAI scores and negative for anti-ds DNA antibody. It is concluded that anti-C1q antibody can serve as a general marker for lupus activity, supplementing the currently used serum markers.en_US
dc.description.affiliationDepartment of Medicine, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationKumar A, Gupta R, Varghese T, Pande RM, Singal VK, Garg OP. Anti-C1q antibody as a marker of disease activity in systemic lupus erythematosus. Indian Journal of Medical Research. 1999 Dec; 110(): 190-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/19291
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntibodies --analysisen_US
dc.subject.meshAntibodies, Antinuclear --analysisen_US
dc.subject.meshBiological Markersen_US
dc.subject.meshComplement C1q --immunologyen_US
dc.subject.meshDNA --immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLupus Erythematosus, Systemic --diagnosisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleAnti-C1q antibody as a marker of disease activity in systemic lupus erythematosus.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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