Microscopic Studies on the Effects of Esomeprazole on the Gastric Mucosa: An Experimental Study in Albino Rat

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dc.contributor.authorAnand, Pallavi Ranjanen_US
dc.contributor.authorGhaus, Farahen_US
dc.contributor.authorFaruqi, Nafis Ahmaden_US
dc.date.accessioned2019-12-02T10:30:48Z
dc.date.available2019-12-02T10:30:48Z
dc.date.issued2018-01
dc.description.abstractBackground: Detailed histopathological and histomorphometric analysis of gastric mucosa after long term treatment or ingestion of esomeprazole specifically is lacking in literature. Methods: 24 male and female rats, 12 each were divided into control and experimental groups (6 each for both sexes). Rats of experimental group got 15 mg/kg body weight of esomeprazole by oral intubation for 130 days. After perfusion fixation by Karnovsky’s solution, two pieces of gastric wall were procured from anterior aspect, 1 each from distal part of body and pyloric region respectively. Sections of 8 μm thickness, obtained by using wax embedding technique, were stained with haematoxylin and eosin. Results: In both the regions of stomach in two sexes of control rats, the mucosa showed 1/5th superficial layer of absorptive epithelial cells,3/5th parietal and deepest 1/5th layer of pepsin secreting glands. Parietal and pepsin gland layers were involved in body of male and pyloric region of female. Marked oedema, hypertrophy and hyperplasia were uniformly observed in experimental animals. Conclusion: Atrophic gastritis observed in female pyloric region is an alarming observation because it is the precursor of gastric carcinoma.en_US
dc.identifier.affiliationsjunior Resident, Department of Anatomy, J N Medical College, Aligarh Muslim University, Aligarh-202002, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Department of Anatomy, J N Medical College, Aligarh Muslim University, Aligarh-202002, Indiaen_US
dc.identifier.affiliationsProfessor, Department of Anatomy, J N Medical College, Aligarh Muslim University, Aligarh-202002, Indiaen_US
dc.identifier.citationAnand Pallavi Ranjan, Ghaus Farah, Faruqi Nafis Ahmad. Incidence of Stillbirth in a Tertiary Medical College in North- Eastern India and its Associated Maternal and Foetal Factors. Annals of International medical and Dental Research. 2018 Jan; 4(1): 1-4en_US
dc.identifier.issn2395-2822
dc.identifier.issn2395-2814
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/187720
dc.languageenen_US
dc.publisherSociety for Health Care & Research Developmenten_US
dc.relation.issuenumber1en_US
dc.relation.volume4en_US
dc.source.urihttps://www.doi.org/10.21276/aimdr.2018.4.1.AT3en_US
dc.subjectEsomeprazoleen_US
dc.subjectGastric Mucosaen_US
dc.titleMicroscopic Studies on the Effects of Esomeprazole on the Gastric Mucosa: An Experimental Study in Albino Raten_US
dc.typeJournal Articleen_US
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