Beyond Immunuhistochemistry: Molecular Insights Into Round Cell Soft Tissue Tumors

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dc.contributor.authorMadoori, PKen_US
dc.contributor.authorTejavat, S.en_US
dc.date.accessioned2025-05-14T09:42:56Z
dc.date.available2025-05-14T09:42:56Z
dc.date.issued2024-12
dc.description.abstractRound cell so? ?ssue tumors (RCSTTs) are a diverse group of aggressive malignancies that share overlapping clinical, morphological, and immunohistochemical features, posing significant diagnos?c challenges. Recent advances in molec- ular pathology have revolu?onized the understanding and classifica?on of these tumors by iden?fying tumor-specific gene?c altera?ons. This review highlights the role of molec- ular insights in complemen?ng histopathology and immuno- histochemistry to achieve precise diagnosis, risk stra?fica- ?on, and therapeu?c decision-making. Key subtypes, includ- ing Ewing sarcoma, CIC- and BCOR-rearranged sarcomas, alveolar rhabdomyosarcoma, desmoplas?c small round cell tumor, and extraskeletal myxoid chondrosarcoma, are dis- cussed with emphasis on their molecular signatures and clin- ical significance. The advent of techniques such as fluo- rescence in situ hybridiza?on (FISH), reverse transcriptase- polymerase chain reac?on (RT-PCR), and next-genera?on sequencing (NGS) has enabled detec?on of gene?c fusions and aberra?ons cri?cal for tumor iden?fica?on and targeted therapies. Integra?on of molecular pathology with tradi- ?onal diagnos?c approaches is essen?al for improving diag- nos?c accuracy, prognos?ca?on, and therapeu?c strategies, paving the way for personalized medicine in the manage- ment of RCSTTs. Full form of ABBREVIATIONS are provided at the end.en_US
dc.identifier.affiliationsAssociate Professor, Department of Pathology, Parul Ins?tute of Medical Sciences and Research, Parul University, Limda, Waghodia, Vadodara, Gujaraten_US
dc.identifier.affiliationsDivision of Pathology, Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabiaen_US
dc.identifier.citationMadoori PK, Tejavat S.. Beyond Immunuhistochemistry: Molecular Insights Into Round Cell Soft Tissue Tumors . Perspectives in Medical Research. 2024 Dec; 12(12): 4-11en_US
dc.identifier.issn2348-1447
dc.identifier.issn2348-229X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247906
dc.languageenen_US
dc.publisherPrathima Institute of Medical Sciencesen_US
dc.relation.issuenumber12en_US
dc.relation.volume12en_US
dc.source.urihttps://www.pimr.org.in/2024-vol12-issue-3/10.47799/pimr.1203.02en_US
dc.subjectChromosomal Aberra?onsen_US
dc.subjectMolecular Pathol-ogyen_US
dc.subjectRound Cell Tumorsen_US
dc.subjectTherapeu?c Targetsen_US
dc.titleBeyond Immunuhistochemistry: Molecular Insights Into Round Cell Soft Tissue Tumorsen_US
dc.typeJournal Articleen_US
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