Clinical profile & predictors of poor outcome of adult HIV-tuberculosis patients in a tertiary care centre in north India.

Simple item page
dc.contributor.authorSharma, Surendra K
dc.contributor.authorSoneja, Manish
dc.contributor.authorPrasad, K T
dc.contributor.authorRanjan, Sanjay
dc.date.accessioned2015-01-14T11:09:52Z
dc.date.available2015-01-14T11:09:52Z
dc.date.issued2014-01
dc.description.abstractBackground & objectives: There is a paucity of data from India on response to treatment of tuberculosis (TB) in patients with human immunodeficiency virus (HIV)-TB co-infection. This study was done to assess the frequency and pattern of TB, outcome of anti-tuberculosis treatment, and the factors related to poor outcome of TB treatment in adult patients with HIV infection. Methods: Retrospective review of case records of HIV-TB co-infected patients attending the antiretroviral therapy (ART) clinic in a tertiary care centre in north India was done. Results: Of the 1754 patients included in the study, 583 (33.2%) were diagnosed with active TB and 466 (79.9%) of them had CD4 count less than 200/μl at diagnosis. Extrapulmonary TB was diagnosed in 372 (63.8%) patients [76 (20.4%) had disseminated TB], and pulmonary TB in 211 (36.2%) patients. “Favourable outcome” (cure and completed treatment) was observed in 332 (77%) patients. Unfavourable outcome included default (8.1%), treatment failure (1.6%), and death (13.2%). At 1-year post-treatment follow up, 12 (3.6%) patients had disease relapse. CD4 count of less than 200/ μl at diagnosis [OR-2.32, CI (1.06-5.09)], and retreatment cases [OR-2.91, CI (1.22-6.89)] were independent predictors of unfavourable outcome. Interpretation & conclusions: There is an urgent need to strengthen the information, education, communication activities and expand the ART services to meet the requirement of early testing and treatment initiation in patients co-infected with HIV-TB. The findings highlight the need for performing drug susceptibility testing (DST) for patients starting retreatment regimen to improve treatment outcome.en_US
dc.identifier.citationSharma Surendra K, Soneja Manish, Prasad K T, Ranjan Sanjay. Clinical profile & predictors of poor outcome of adult HIV-tuberculosis patients in a tertiary care centre in north India. Indian Journal of Medical Research. 2014 Jan; 139(1): 154-160.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/155138
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994731/en_US
dc.subjectAcquired immune deficiency syndromeen_US
dc.subjectclinical profileen_US
dc.subjecthuman immunodeficiency virusen_US
dc.subjectimmunosuppressionen_US
dc.subjecttuberculosisen_US
dc.titleClinical profile & predictors of poor outcome of adult HIV-tuberculosis patients in a tertiary care centre in north India.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijmr2014v139n1p154.pdf
Size:
327.58 KB
Format:
Adobe Portable Document Format
Description:
Original articles
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Medical Research