Thailand diabetes registry project: prevalence, characteristics and treatment of patients with diabetic nephropathy.

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dc.contributor.authorNgarmukos, Chardpraornen_US
dc.contributor.authorBunnag, Pongamornen_US
dc.contributor.authorKosachunhanun, Natapongen_US
dc.contributor.authorKrittiyawong, Sirinateen_US
dc.contributor.authorLeelawatana, Rattanaen_US
dc.contributor.authorPrathipanawatr, Thongchaien_US
dc.contributor.authorPlengvidhya, Nattacheten_US
dc.contributor.authorBenjasuratwong, Yupinen_US
dc.contributor.authorSuwanwalaikorn, Sompongseen_US
dc.contributor.authorDeerochanawong, Chaicharnen_US
dc.contributor.authorChetthakul, Thanyaen_US
dc.contributor.authorMongkolsomlit, Sirimaen_US
dc.contributor.authorRawdaree, Petchen_US
dc.date.accessioned2009-05-27T19:15:43Z
dc.date.available2009-05-27T19:15:43Z
dc.date.issued2006-08-25en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVES: To identify the prevalence and characteristics of patients with Diabetic Nephropathy (DN) and to evaluate adequacy of glycemic and blood pressure control of these patients in the authors' registry. MATERIAL AND METHOD: A cross-sectional, multicenter, hospital-based diabetic registry was carried out in diabetes clinics of 11 tertiary centers in Thailand. DN was defined as the presence of at least two out of three of these symptoms; positive microalbuminuria, positive dipstick proteinuria or creatinine levels equal to or greater than 2 mg/dl. One center that did not perform urine microalbumin measurement was excludedfrom the analysis. Overt nephropathy was defined as the presence of gross proteinuria or renal insufficiency. RESULTS: The study included 4875 patients (females 63.8%) with a mean (SD) duration ofdiabetes of 12.8 (8.2) years. The prevalence of DN was 42.9% (microalbuminuria 19.7% and overt nephropathy 23.2%). There were 373 (7.7%) patients with renal insufficiency and 24 (0.47%) with end-stage renal disease. By multivariate analysis, factors associated with DN were age, duration of diabetes, male sex, smoking, blood pressure, HbA1c, dyslipidemia and presence of diabetic retinopathy. Prevalence of ischemic heart disease and cerebrovascular disease in patients with DN was 11.5% and 6.6% respectively. Mean (SD) HbA1c in patients with nephropathy was 8.2 (2.6)%. Only 25% of subject had HbA1c of less than 7%, 46% had blood pressure ofmore than 140/90 mmHg and 84% received at least one antihypertensive drug. However, the target blood pressure of less than 130/80 mmHg could be achieved in only 18% of these patients. The mean (SD) number of antihypertensive drugs was 1.7 (1.1). Nearly 60% of patients received either ACE inhibitors or ARBs. CONCLUSION: DN was very common. The overall picture of DN in the present survey suggests the seriousness of the problem and prompts more aggressive intervention.en_US
dc.description.affiliationDepartment of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. tecng@mahidol.ac.then_US
dc.identifier.citationNgarmukos C, Bunnag P, Kosachunhanun N, Krittiyawong S, Leelawatana R, Prathipanawatr T, Plengvidhya N, Benjasuratwong Y, Suwanwalaikorn S, Deerochanawong C, Chetthakul T, Mongkolsomlit S, Rawdaree P. Thailand diabetes registry project: prevalence, characteristics and treatment of patients with diabetic nephropathy. Journal of the Medical Association of Thailand. 2006 Aug; 89 Suppl 1(): S37-42en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40784
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAntihypertensive Agents --therapeutic useen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDiabetes Mellitus, Type 1 --physiopathologyen_US
dc.subject.meshDiabetes Mellitus, Type 2 --physiopathologyen_US
dc.subject.meshDiabetic Nephropathies --drug therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshProgram Developmenten_US
dc.subject.meshRegistriesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshThailand --epidemiologyen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleThailand diabetes registry project: prevalence, characteristics and treatment of patients with diabetic nephropathy.en_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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