Expression of CyclinD1, p27kp-1, and bcl-2 in plexiform neurofibroma with and without malignant transformation in neurofibromatosis type 1.

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dc.contributor.authorThanakit, Voranuchen_US
dc.contributor.authorShuangshoti, Shanopen_US
dc.contributor.authorRuangvejvorachai, Preechaen_US
dc.date.accessioned2009-05-27T19:41:35Z
dc.date.available2009-05-27T19:41:35Z
dc.date.issued2006-09-28en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractPlexiform neurofibroma (PNF) has a low potential to undergo malignant transformation. Identification of markers associated with tumor progression is important since it may serve as prognostic indicators or adjuncts to standard pathological examination. In the present study, the authors immunostained 20 neurofibromatosis type I-associated PNFs with cyclinD1, p27kip-1, and bcl-2. Six of the cases had progressed into malignant peripheral nerve sheath tumor (MPNST), and the transitional area of each sample was also stained separately in order to identify protein(s) associated with tumor progression. Cyclin D1 was found to be significantly increased in the transitional zone, compared to the ordinary PNF (p = 0.007). The protein is, thus, likely to play a role in the malignant transformation. There was no significant difference in the expression of p27kip-1 and bcl-2 during the malignant progression of PNF.en_US
dc.description.affiliationDepartment of Pathology, Chulalongkorn University, Bangkok 10330. Thailand. voranewt@yahoo.comen_US
dc.identifier.citationThanakit V, Shuangshoti S, Ruangvejvorachai P. Expression of CyclinD1, p27kp-1, and bcl-2 in plexiform neurofibroma with and without malignant transformation in neurofibromatosis type 1. Journal of the Medical Association of Thailand. 2006 Sep; 89 Suppl 3(): S53-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/41610
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshCell Transformation, Neoplasticen_US
dc.subject.meshChilden_US
dc.subject.meshCyclin D1 --metabolismen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIntracellular Signaling Peptides and Proteins --metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeurofibroma, Plexiform --metabolismen_US
dc.subject.meshNeurofibromatosis 1 --metabolismen_US
dc.subject.meshProto-Oncogene Proteins c-bcl-2 --metabolismen_US
dc.subject.meshTumor Markers, Biological --metabolismen_US
dc.titleExpression of CyclinD1, p27kp-1, and bcl-2 in plexiform neurofibroma with and without malignant transformation in neurofibromatosis type 1.en_US
dc.typeJournal Articleen_US
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