Oleuropein ameliorates hyperlipidemia, oxidative stress, inflammatory and liver dysfunction biomarkers, in streptozotocin-induced diabetic rats

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dc.contributor.authorMohamed, NAen_US
dc.contributor.authorHussein, MMen_US
dc.contributor.authorAhmed, OMen_US
dc.contributor.authorAl-Jameel, SSen_US
dc.contributor.authorAl-Muzafar, HMen_US
dc.contributor.authorAmin, KAen_US
dc.contributor.authorAbdou, HMen_US
dc.date.accessioned2024-11-30T11:21:20Z
dc.date.available2024-11-30T11:21:20Z
dc.date.issued2024-09
dc.description.abstractDiabetes mellitus (DM) is a serious threat factor for chronic liver disorders and the development of nonalcoholic steatohepatitis into cirrhosis. However, numerous pharmacological actions of olive polyphenol have been discovered, with oleuropein being a primary phenolic substance found in olive leaves, olive oil, and olive fruit (Olea europaea). Our goal is to identify the impacts of oleuropein on lipid measurements, oxidative stress, serum leptin, adiponectin levels, inflammatory status, and hepatic dysfunctions in a male rat model with streptozotocin (STZ)-induced DM. Oleuropein was orally administered to diabetic rats at a 5 mg/kg bw/day dose for 15 days. Diabetic rats treated with oleuropein demonstrated improved hepatic function test results (ALT, AST, alkaline phosphatase, and bilirubin), while activity of the low liver glucose-6-phosphate dehydrogenase (G6PDH) increased. Moreover, serum triacylglycerol, very low-density lipoprotein, low-density lipoprotein, and total cholesterol (TC) were considerably reduced, while high-density lipoprotein increased markedly. In addition, serum antioxidative enzymes such as glutathione peroxidase, catalase, glutathione-S-transferase, and superoxide dismutase increased, as well as glutathione levels. Lipid peroxidation levels were lower than those in the STZ control group. Treating diabetic rats with oleuropein not only resulted in decreased serum leptin and increased adiponectin levels but also had a substantial inhibitory effect on the elevated COX-2 and TNF-? mRNA expression levels in the livers of the STZ group. In conclusion, oleuropein has shown promising results in mitigating hyperlipidemia, oxidative stress, inflammation, and hepatic dysfunction biomarkers in diabetic rats.en_US
dc.identifier.affiliationsDepartment of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypten_US
dc.identifier.affiliationsDepartment of Zoology, Faculty of Science, Omar El-Mokhtar University, Tripoli, Libyaen_US
dc.identifier.affiliationsPhysiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypten_US
dc.identifier.affiliationsDepartment of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; Basic and Applied Scientific Research Center (BASRC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabiaen_US
dc.identifier.affiliationsDepartment of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; Basic and Applied Scientific Research Center (BASRC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabiaen_US
dc.identifier.affiliationsDepartment of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; Basic and Applied Scientific Research Center (BASRC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabiaen_US
dc.identifier.affiliationsDepartment of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt.en_US
dc.identifier.citationMohamed NA, Hussein MM, Ahmed OM, Al-Jameel SS, Al-Muzafar HM, Amin KA, Abdou HM. Oleuropein ameliorates hyperlipidemia, oxidative stress, inflammatory and liver dysfunction biomarkers, in streptozotocin-induced diabetic rats. Journal of Applied Pharmaceutical Science. 2024 Sept; 14(9): 227-234en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237702
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber9en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.7324/JAPS.2024.167994en_US
dc.subjectDiabetes mellitusen_US
dc.subjectoleuropeinen_US
dc.subjectliveren_US
dc.subjectantioxidantsen_US
dc.subjectinflammationen_US
dc.subjectrats.en_US
dc.titleOleuropein ameliorates hyperlipidemia, oxidative stress, inflammatory and liver dysfunction biomarkers, in streptozotocin-induced diabetic ratsen_US
dc.typeJournal Articleen_US
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