Sceletium Tortuosum: Effects on Central Nervous System and Related Disease

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dc.contributor.authorLuo, Yangwenen_US
dc.contributor.authorWen, Jingen_US
dc.contributor.authorKanfer, Isadoreen_US
dc.contributor.authorYu, Peien_US
dc.contributor.authorPatnala, Srinivasen_US
dc.date.accessioned2020-11-18T10:29:11Z
dc.date.available2020-11-18T10:29:11Z
dc.date.issued2020-06
dc.description.abstractSceletium tortuosum is a well-known medicinal plant in South Africa with potential applications. Its rawmaterial, extracts and isolated alkaloids are used as dietary supplements, natural medicines and health food.In this paper, methods of planting, extraction, isolation and identification of Sceletium tortuosum, as well as itschemical structure of main extracted alkaloids, their related pharmacological effects and mechanisms fortreating the disease are reviewed. In general, Sceletium tortuosum is active to central nervous system (CNS) byinhibiting phosphodiesterase isozyme 4 (PDE4), serotonin (5-HT) uptake and acetylcholinesterase (AChE). Italso acts as a monoamine releasing agent for antidepressant effects. Therefore, it is a useful therapeutic agentin clinical use.en_US
dc.identifier.affiliationsCollege of Pharmacy, Jinan University, Guangzhou, Chinaen_US
dc.identifier.affiliationsFaculty of Pharmacy, Rhodes University, Grahamstown, South Africaen_US
dc.identifier.citationLuo Yangwen, Wen Jing, Kanfer Isadore, Yu Pei, Patnala Srinivas. Sceletium Tortuosum: Effects on Central Nervous System and Related Disease. Journal of Pharmaceutical and Biomedical Sciences. 2020 Jun; 10(6): 151-160en_US
dc.identifier.issn2230-7885
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215719
dc.languageenen_US
dc.publisherLawarence Press Pvt. Ltd.en_US
dc.relation.issuenumber6en_US
dc.relation.volume10en_US
dc.source.urihttps://lawarencepress.com/ojs/index.php/JPBMS/article/view/618/pdf_302en_US
dc.subjectSceletium tortuosumen_US
dc.subjectalkaloidsen_US
dc.subjectphosphodiesterase isozyme 4en_US
dc.subject5-hydroxytryptamineen_US
dc.subjectcentral nervous systemen_US
dc.titleSceletium Tortuosum: Effects on Central Nervous System and Related Diseaseen_US
dc.typeJournal Articleen_US
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