Detection of BCR/ABL fusion gene in CML: a preliminary report.

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dc.contributor.authorRerkamnuaychoke, Ben_US
dc.contributor.authorKangwanpong, Den_US
dc.contributor.authorJootar, Sen_US
dc.contributor.authorPuranakanitstha, Cen_US
dc.date.accessioned2009-05-27T15:13:12Z
dc.date.available2009-05-27T15:13:12Z
dc.date.issued1995-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe BCR/ABL fusion gene in 31 patients with chronic myeloid leukemia (CML) was detected by RT/PCR. In 18 cases of Ph' positive patients, 13 had BCR 3/ABL II rearrangement, 1 had BCR 2/ABL II rearrangement and 4 had both rearrangements. One case with complex translocation: 46,XY,t(9;9;22), had BCR 3/ABL II rearrangement. In 8 cases of Ph' negative patients, 4 had BCR 3/ABL II rearrangement, 3 had both rearrangements while 1 had no BCR/ABL rearrangement. Interestingly, in 4 patients who had no cytogenetic result, we could observe BCR 3/ABL II rearrangement in 3 cases and both rearrangements in 1 case. The results suggest that this procedure is sensitive and independent of the presence or absence of an identifiable Ph' chromosome.en_US
dc.description.affiliationDepartment of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Thailand.en_US
dc.identifier.citationRerkamnuaychoke B, Kangwanpong D, Jootar S, Puranakanitstha C. Detection of BCR/ABL fusion gene in CML: a preliminary report. The Southeast Asian Journal of Tropical Medicine and Public Health. 1995 ; 26 Suppl 1(): 197-200en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/32225
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshBone Marrow --pathologyen_US
dc.subject.meshExonsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFusion Proteins, bcr-abl --biosynthesisen_US
dc.subject.meshGene Rearrangementen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshPhiladelphia Chromosomeen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshTranscription, Geneticen_US
dc.titleDetection of BCR/ABL fusion gene in CML: a preliminary report.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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