Immunohistochemical typing of non-Hodgkin's lymphoma-comparing working formulation and WHO classification.

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dc.contributor.authorKalyan, Kotien_US
dc.contributor.authorBasu, Debdattaen_US
dc.contributor.authorSoundararaghavan, Jayanthien_US
dc.date.accessioned2006-04-29en_US
dc.date.accessioned2009-05-29T12:25:51Z
dc.date.available2006-04-29en_US
dc.date.available2009-05-29T12:25:51Z
dc.date.issued2006-04-29en_US
dc.description.abstractThe recent WHO classification of non-Hodgkin's lymphoma is based on the morphology and immunohistochemical expression of the lymphoma cells and to a lesser extent, on the molecular and cytogenetic findings. Fifty-three cases of non-Hodgkin's lymphoma were included in the study. Of these, seven cases were primary extra nodal lymphomas. Twenty two patients had peripheral blood and/or bone marrow involvement. A detailed morphological assessment was done and classified using the International working formulation. The two most common types encountered were diffuse large cell lymphoma and small lymphocytic lymphoma. Immunohistochemistry was done using labeled streptavidin-biotin peroxidase complex with CD3, CD20, CD15, CD30, CD 45 (leukocyte common antigen), Cyclin D1, EMA (epithelial membrane antigen). 38 cases (72%) showed B cell expression and 12 cases (22.5%) showed T cell expression. Three cases did not express either marker. B-cell diffuse large cell lymphoma (26%) was found to be the predominant B cell non-Hodgkin's lymphoma. The commonest T-cell lymphoma was T lymphoblastic lymphoma (67%) followed by peripheral T cell angioimmunoblastic lymphoma (25%). Immunohistochemistry is a useful and necessary diagnostic modality and helps subdivide prognostically different types of non-Hodgkin's lymphoma.en_US
dc.description.affiliationDepartment of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry.en_US
dc.identifier.citationKalyan K, Basu D, Soundararaghavan J. Immunohistochemical typing of non-Hodgkin's lymphoma-comparing working formulation and WHO classification. Indian Journal of Pathology & Microbiology. 2006 Apr; 49(2): 203-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/74581
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntigens, CD20 --metabolismen_US
dc.subject.meshAntigens, CD3 --metabolismen_US
dc.subject.meshB-Lymphocytes --immunologyen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLymphoma, Non-Hodgkin --classificationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshT-Lymphocytes --immunologyen_US
dc.subject.meshWorld Health Organizationen_US
dc.titleImmunohistochemical typing of non-Hodgkin's lymphoma-comparing working formulation and WHO classification.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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