Simulated field evaluation of the efficacy of two formulations of diflubenzuron, a chitin synthesis inhibitor against larvae of Aedes aegypti (L.) (Diptera: Culicidae) in water-storage containers.

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dc.contributor.authorThavara, Usavadeeen_US
dc.contributor.authorTawatsin, Apiwaten_US
dc.contributor.authorChansang, Chittien_US
dc.contributor.authorAsavadachanukorn, Preechaen_US
dc.contributor.authorZaim, Mortezaen_US
dc.contributor.authorMulla, Mir Sen_US
dc.date.accessioned2009-05-27T16:47:46Z
dc.date.available2009-05-27T16:47:46Z
dc.date.issued2007-03-02en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractTablet (40 mg a.i./tablet) and granular (2% a.i.) formulations of diflubenzuron, a chitin synthesis inhibitor, insect growth regulator, were evaluated for larvicidal efficacy against the larvae of Aedes aegypti (L.) in water-storage containers under field conditions in Thailand. Each formulation was applied to 200-1 clay jars at 5 different dosages (0.02, 0.05, 0.1, 0.5 and 1 mg/l a.i.). The jars were covered with solid celocrete sheets and placed in the shade under a roof. Another experiment was also carried out using 3 different dosages (0.1, 0.5 and 1 mg/l) where half the water in each treated jar and the control was removed and refilled weekly. Each treatment was replicated four times. The treatments were challenged by adding 25 3rd instar larvae/jar weekly. Assessments were made of each treatment through emergence inhibition (%EI) by removing and counting pupal skins one week after larval addition. Using these assessment techniques, a high degree of larvicidal efficacy (96-100%EI) was achieved with 4 dosages (0.05, 0.1, 0.5 and 1 mg/l) of both (tablet and granular) formulations for a period of 23 weeks post-treatment. The efficacy of the lowest dosage (0.02 mg/l) of tablet and granular formulations lasted for 21 and 22 weeks post-treatment, respectively. Under the conditions of water removal and weekly refilling, a high degree of larvicidal efficacy (96-100%El) at the 3 dosages was obtained with the tablet formulation 18 to 21 weeks post-treatment, whereas the efficacy of the granular formulation persisted 15 to 23 weeks post-treatment depending on the dosage. This study clearly demonstrates a high level of residual activity with both formulations of diflubenzuron against larvae of Ae. aegypti in water-storage containers. Considering environmental factors and water-use conditions, it is likely that dosages of 0.05 to 0.1 mg a.i./l are effective dosages providing long-lasting control for 3 to 4 months in the field.en_US
dc.description.affiliationNational Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand. usavadee@dmsc.moph.go.then_US
dc.identifier.citationThavara U, Tawatsin A, Chansang C, Asavadachanukorn P, Zaim M, Mulla MS. Simulated field evaluation of the efficacy of two formulations of diflubenzuron, a chitin synthesis inhibitor against larvae of Aedes aegypti (L.) (Diptera: Culicidae) in water-storage containers. The Southeast Asian Journal of Tropical Medicine and Public Health. 2007 Mar; 38(2): 269-75en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36029
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2007_38_2/09-3948.pdfen_US
dc.subject.meshAedes --growth & developmenten_US
dc.subject.meshAnimalsen_US
dc.subject.meshChitin --antagonists & inhibitorsen_US
dc.subject.meshDiflubenzuron --pharmacologyen_US
dc.subject.meshDiptera --parasitologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshInsect Vectors --drug effectsen_US
dc.subject.meshInsecticides --administration & dosageen_US
dc.subject.meshLarva --drug effectsen_US
dc.subject.meshMosquito Control --methodsen_US
dc.subject.meshPupa --growth & developmenten_US
dc.subject.meshThailanden_US
dc.subject.meshWater --parasitologyen_US
dc.subject.meshWater Supplyen_US
dc.titleSimulated field evaluation of the efficacy of two formulations of diflubenzuron, a chitin synthesis inhibitor against larvae of Aedes aegypti (L.) (Diptera: Culicidae) in water-storage containers.en_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
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