Adenosine-induced chest pain: is it due to myocardial ischaemia? Clinical, electrocardiographic, haemodynamic and metabolic study.

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dc.contributor.authorMehta, A Ben_US
dc.contributor.authorMardikar, H Men_US
dc.contributor.authorHiregoudar, N Sen_US
dc.contributor.authorSethi, R Ben_US
dc.contributor.authorSolanki, D Ren_US
dc.contributor.authorMathew, Ren_US
dc.date.accessioned1997-05-01en_US
dc.date.accessioned2009-05-27T04:22:34Z
dc.date.available1997-05-01en_US
dc.date.available2009-05-27T04:22:34Z
dc.date.issued1997-05-01en_US
dc.description.abstractAdenosine has recently been demonstrated to be a mediator of angina in human beings. The present study was undertaken to document the presence or absence of myocardial ischaemia on clinical, haemodynamic, electrocardiographic and metabolic evidences after intracoronary administration of adenosine. Fifteen patients with chronic stable angina (12 males and 3 females), positive exercise stress test and documented significant stenosis of the left anterior descending coronary artery (LAD) were included in the study. The surface and intracoronary electrocardiograms (ECGs), pulmonary artery diastolic pressure and coronary sinus lactate levels were monitored at baseline and after intracoronary administration of adenosine in all patients. Adenosine was administered intracoronary in doses of 1000-8000 microgram depending on the provocation of chest pain. Typical angina was observed in all patients. There were no signs of ischaemia on surface or intracoronary ECG. There was no statistically significant difference between the pulmonary artery diastolic pressure and coronary sins lactate levels at baseline and post-adenosine administration (p > 0.05). It is concluded that intracoronary administration of adenosine produces chest pain in patients with chronic stable angina by mechanism other than myocardial ischaemia.en_US
dc.description.affiliationDepartment of Cardiology, LTMM College, Bombay.en_US
dc.identifier.citationMehta AB, Mardikar HM, Hiregoudar NS, Sethi RB, Solanki DR, Mathew R. Adenosine-induced chest pain: is it due to myocardial ischaemia? Clinical, electrocardiographic, haemodynamic and metabolic study. Indian Heart Journal. 1997 May-Jun; 49(3): 267-70en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/4311
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAdenosine --diagnostic useen_US
dc.subject.meshAngina Pectoris --chemically induceden_US
dc.subject.meshElectrocardiographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemodynamics --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshInfusions, Intra-Arterialen_US
dc.subject.meshIschemic Preconditioning, Myocardialen_US
dc.subject.meshLactic Acid --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardial Ischemia --diagnosisen_US
dc.subject.meshPulmonary Wedge Pressure --physiologyen_US
dc.subject.meshReceptors, Purinergic P1 --drug effectsen_US
dc.titleAdenosine-induced chest pain: is it due to myocardial ischaemia? Clinical, electrocardiographic, haemodynamic and metabolic study.en_US
dc.typeJournal Articleen_US
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