Evaluation of oxidative stress before and after haemodialysis in chronic renal failure.

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dc.contributor.authorChugh, S Nen_US
dc.contributor.authorJain, Sen_US
dc.contributor.authorAgrawal, Nen_US
dc.contributor.authorSharma, Aen_US
dc.date.accessioned2000-10-24en_US
dc.date.accessioned2009-05-31T03:08:34Z
dc.date.available2000-10-24en_US
dc.date.available2009-05-31T03:08:34Z
dc.date.issued2000-10-24en_US
dc.description.abstractOBJECTIVE: To evaluate the oxidative stress before and after haemodialysis in chronic renal failure patients. METHODS: A prospective study comprising of 22 patients of CRF who have to receive their first haemodialysis. All patients were subjected to standard four hours haemodialysis. The parameters of oxidative stress i.e. erythrocyte malonaldehyde (MDA), reduced glutathione (GSH) and superoxide dismutase (SOD) were measured before and after haemodialysis. RESULTS: The value of mean erythrocyte MDA (9.40 +/- 3.36 mumol/L) and SOD (617 +/- 64.33 units/ml) were significantly higher in patients of CRF before haemodialysis than in controls (p < 0.001). The mean GSH levels were significantly lower (451 +/- 63.91 micrograms/ml) in patients than in controls before haemodialysis (p < 0.001). After haemodialysis MDA levels further increased (12.27 +/- 4.38 mumol/L), SOD levels decreased (458 +/- 69.58 EU/ml) and GSH levels further decreased (396 +/- 41.41 micrograms/ml) (p < 0.001). CONCLUSIONS: There was an evidence of oxidative stress in patients of CRF before haemodialysis which increased further after haemodialysis, the mechanisms of which is not delineated. The procedural factors may be contributing in the increased oxidative stress after haemodialysis.en_US
dc.description.affiliationDepartment of Biochemistry, Pt. BD Sharma PGIMS, Rohtak.en_US
dc.identifier.citationChugh SN, Jain S, Agrawal N, Sharma A. Evaluation of oxidative stress before and after haemodialysis in chronic renal failure. Journal of the Association of Physicians of India. 2000 Oct; 48(10): 981-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/93648
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlutathione --metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Failure, Chronic --diagnosisen_US
dc.subject.meshMaleen_US
dc.subject.meshMalondialdehyde --metabolismen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOxidative Stress --physiologyen_US
dc.subject.meshProbabilityen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRenal Dialysis --methodsen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshSuperoxide Dismutase --metabolismen_US
dc.subject.meshTime Factorsen_US
dc.titleEvaluation of oxidative stress before and after haemodialysis in chronic renal failure.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
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