Use of specific polyclonal antibodies for site specific drug targeting to malaria infected erythrocytes in vivo.

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dc.contributor.authorSingh, A Men_US
dc.contributor.authorOwais, Men_US
dc.contributor.authorVarshney, G Cen_US
dc.date.accessioned1993-12-01en_US
dc.date.accessioned2009-05-27T09:23:42Z
dc.date.available1993-12-01en_US
dc.date.available2009-05-27T09:23:42Z
dc.date.issued1993-12-01en_US
dc.description.abstractThe possibility of using specific polyclonal antibodies for effective site specific drug targeting to malaria infected erythrocytes has been examined. For this purpose, rabbit polyclonal antiserum was raised against Plasmodium berghei infected mouse erythrocytes (IRBC) and extensively absorbed with normal erythrocytes (NRBC). Absorbed antiserum specifically recognized IRBC. F(ab')2-fragments of these antibodies were coupled to chloroquine (chq) laden liposomes. These immunoliposomes when tested in vivo significantly suppressed malarial infection in mice.en_US
dc.description.affiliationInstitute of Microbial Technology, Chandigarh, India.en_US
dc.identifier.citationSingh AM, Owais M, Varshney GC. Use of specific polyclonal antibodies for site specific drug targeting to malaria infected erythrocytes in vivo. Indian Journal of Biochemistry & Biophysics. 1993 Dec; 30(6): 411-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/27373
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodiesen_US
dc.subject.meshAntibody Specificityen_US
dc.subject.meshChloroquine --administration & dosageen_US
dc.subject.meshDrug Carriersen_US
dc.subject.meshErythrocytes --immunologyen_US
dc.subject.meshImmunoglobulin Fab Fragmentsen_US
dc.subject.meshLiposomesen_US
dc.subject.meshMalaria --blooden_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred BALB Cen_US
dc.subject.meshPlasmodium bergheien_US
dc.titleUse of specific polyclonal antibodies for site specific drug targeting to malaria infected erythrocytes in vivo.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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