Oxidative stress in patients with essential hypertension.

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dc.contributor.authorTandon, Ren_US
dc.contributor.authorSinha, M Ken_US
dc.contributor.authorGarg, Hen_US
dc.contributor.authorKhanna, Ren_US
dc.contributor.authorKhanna, H Den_US
dc.date.accessioned2005-11-18en_US
dc.date.accessioned2009-06-03T05:53:28Z
dc.date.available2005-11-18en_US
dc.date.available2009-06-03T05:53:28Z
dc.date.issued2005-11-18en_US
dc.description.abstractBACKGROUND: Free oxygen radicals react with membrane lipids to form lipid hydroperoxides, a destructive process known as lipid peroxidation. Lipid hydroperoxides decompose to form a variety of products including malondialdehyde, which is used as an indicator of the oxidative damage of cells and tissues. Endogenous antioxidant enzymes such as superoxide dismutase counteract the oxidative damage from oxidative stress. There is increasing evidence that free radicals are involved in the pathogenesis of hypertension by altering endothelial function. We evaluated the oxidative stress and endogenous enzymatic antioxidant status in patients with essential hypertension before and 3 months after treatment with antihypertensives. METHODS: Fifty patients with essential hypertension attending the outpatient services of the Department of Medicine, Institute of Medical Sciences, Banaras Hindu University and 20 age- and sex-matched healthy controls were studied. The serum malondialdehyde and superoxide dismutase levels were measured in patients at the time of presentation and after 3 months of antihypertensive treatment. No antioxidants were given to the patients during the period of the study. RESULTS: The mean (SD) serum malondialdehyde level was found to be significantly higher (0.33 [0.07] mmol/L) in patients with hypertension compared with controls (0.21 [0.05] mmol/L; p < 0.001). This showed a significant decrease following antihypertensive therapy (0.23 [0.06] mmol/L; p < 0.001) compared with pre-treatment values. The serum superoxide dismutase activity was significantly lower in patients (6.93 [1.35] mg protein/ml of serum) compared with controls (20.12 [3.65] mg protein/ml serum; p < 0.001) at the time of presentation and, compared with the pre-treatment values, increased significantly after 3 months of treatment (10.66 [2.91] mg protein/ml of serum; p < 0.001). CONCLUSION: Our study shows that essential hypertension is associated with increased oxidative stress and reduced antioxidant status. Adequate control of blood pressure with antihypertensive therapy decreases oxidative stress and improves the antioxidant status in these patients.en_US
dc.description.affiliationInstitute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.en_US
dc.identifier.citationTandon R, Sinha MK, Garg H, Khanna R, Khanna HD. Oxidative stress in patients with essential hypertension. National Medical Journal of India. 2005 Nov-Dec; 18(6): 297-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/118676
dc.language.isoengen_US
dc.source.urihttps://www.nmji.inen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension --enzymologyen_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshMaleen_US
dc.subject.meshMalondialdehyde --blooden_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshSuperoxide Dismutase --blooden_US
dc.titleOxidative stress in patients with essential hypertension.en_US
dc.typeJournal Articleen_US
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