Role of Phenazopyridine in Urinary Tract Infections.
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Date
2012-02
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Abstract
Irritative voiding symptoms, urinary urgency, frequency, nocturia, painful voiding, bladder discomfort or stranguria, are to
the urinary tract much as a cough is to the pulmonary system, i.e., they are a nonspecific manifestation of multiple potential
underlying causes. Urinary tract infections (UTIs) are usually associated with irritative voiding symptoms, such as painful
urination (dysuria), urinary urgency and frequency. Anticholinergic drugs like flavoxate, oxybutynin provide beneficial
symptomatic relief. However, they have associated adverse anticholinergic effects, such as dry mouth, which hinders patient
compliance. Phenazopyridine hydrochloride acts as a topical analgesic on the mucosal lining of the urinary tract and thus
relieves the irritative symptoms associated with UTI. It is compatible with antibiotics and relieves pain during the interval
before the antibiotic begins to control the infection. It is well-tolerated as it lacks the anticholinergic side effects of other
anticholinergics.
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Keywords
Irritative voiding symptoms, anticholinergics, UTI, patient compliance, phenazopyridine hydrochloride
Citation
Gupta O P, Aggarwal K K. Role of Phenazopyridine in Urinary Tract Infections. Indian Journal of Clinical Practice. 2012 Feb; 22(9): 437-442.