Sensitivity pattern of gram negative bacilli to three beta-lactam/beta-lactamase inhibitor combinations using the automated API system.

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dc.contributor.authorAnuradha, Ken_US
dc.contributor.authorSailaja, V Ven_US
dc.contributor.authorUmabala, Pen_US
dc.contributor.authorSatheesh, Ten_US
dc.contributor.authorLakshmi, Ven_US
dc.date.accessioned2007-07-29en_US
dc.date.accessioned2009-05-28T09:24:44Z
dc.date.available2007-07-29en_US
dc.date.available2009-05-28T09:24:44Z
dc.date.issued2007-07-29en_US
dc.description.abstractPURPOSE: To evaluate the spectrum of activity of three beta-lactamase inhibitors such as amoxicillin/ clavulanic acid, ticarcillin/ clavulanic acid and piperacillin/ tazobactam in comparison to cephalosporins against gram negative bacilli. METHODS: Gram-negative bacilli isolated from the clinical specimens received in the laboratory were included in the study. Using the API system (bioMiotarieux) during a one-year period, a total of 1,252 Enterobacteriaceae and 385 non-fermenters were evaluated. RESULTS: The percentage resistance of the Enterobacteriaceae isolates was 82.92% to amoxicillin/ clavulanic acid, 58.22% to ticarcillin/clavulanic acid and 22.44% to piperacillin/tazobactam respectively. Pseudomonas aeruginosa showed resistance of 96% to ticarcillin/ clavulanic acid and 61% to piperacillin/ tazobactam and Acinetobacter baumannii showed 49% resistance to ticarcillin/ clavulanic acid and 77% resistance to piperacillin/ tazobactam respectively. The isolates exhibited high resistance to all the generations of cephalosporins and the other groups of antibiotics except carbapenems. CONCLUSIONS: Piperacillin/tazobactam was found to be the most active combination of the three against Enterobacteriaceae and Pseudomonas spp. and ticarcillin/clavulanic acid against Acinetobacter spp. and Stenotrophomonas maltophilia.en_US
dc.description.affiliationDepartment of Microbiology, Nizam's Institute of Medical Sciences, Hyderabad - 500 082, Andhra Pradesh, India.en_US
dc.identifier.citationAnuradha K, Sailaja VV, Umabala P, Satheesh T, Lakshmi V. Sensitivity pattern of gram negative bacilli to three beta-lactam/beta-lactamase inhibitor combinations using the automated API system. Indian Journal of Medical Microbiology. 2007 Jul; 25(3): 203-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/53886
dc.language.isoengen_US
dc.source.urihttps://www.ijmm.orgen_US
dc.subject.meshAcinetobacter --drug effectsen_US
dc.subject.meshAmoxicillin --pharmacologyen_US
dc.subject.meshClavulanic Acid --pharmacologyen_US
dc.subject.meshEnterobacteriaceae --drug effectsen_US
dc.subject.meshEnzyme Inhibitors --pharmacologyen_US
dc.subject.meshGram-Negative Bacteria --drug effectsen_US
dc.subject.meshMicrobial Sensitivity Tests --methodsen_US
dc.subject.meshPenicillanic Acid --analogs & derivativesen_US
dc.subject.meshPiperacillin --pharmacologyen_US
dc.subject.meshPseudomonas --drug effectsen_US
dc.subject.meshStenotrophomonas --drug effectsen_US
dc.subject.meshTicarcillin --pharmacologyen_US
dc.subject.meshbeta-Lactam Resistanceen_US
dc.subject.meshbeta-Lactamases --antagonists & inhibitorsen_US
dc.subject.meshbeta-Lactams --pharmacologyen_US
dc.titleSensitivity pattern of gram negative bacilli to three beta-lactam/beta-lactamase inhibitor combinations using the automated API system.en_US
dc.typeJournal Articleen_US
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