Validity of FNAC for the Diagnosis of Leprosy

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dc.contributor.authorBaddam, GSCen_US
dc.contributor.authorSana, VPen_US
dc.contributor.authorMaddali, Men_US
dc.contributor.authorRamachandra, Sen_US
dc.date.accessioned2020-04-10T01:21:43Z
dc.date.available2020-04-10T01:21:43Z
dc.date.issued2018-06
dc.description.abstractEarly and accurate diagnosis of leprosy is crucial because delay may lead to some permanent disability and sequelae. Histopathological examination of skin and nerves and slit skin smears examination to assess the bacillary load, have been the major tools used in the laboratory diagnosis, classification and follow up of patients with leprosy. Histopathological evaluation is not feasible in many leprosy endemic areas. Fine needle aspiration cytology (FNAC) is a simpler tool compared to histopathology for the evaluation of the cytomorphology of skin lesions. Aims of this study are to evaluate the role of cytology in diagnosing leprosy patients, to study the cytomorphology of leprosy lesions in fine needle aspirates and to compare the diagnostic value of FNAC with that of standard histopathological diagnosis. Sensitivity of FNAC in diagnosing leprosy was observed to be BT (87.5%); LL (80%); TT and BL (66.67%) in the descending order. Specificity of FNAC in diagnosing leprosy was in the following order BL (96.29%); followed by LL (96%); TT (92.59%) and BT (85.71%). Positive predictive value was observed to be BT-87.5%; LL-80%; BL-66.67% and TT-50%. Fairly good correlation was observed between clinical, histological and cytomorphological features in the aspirates taken from the skin lesions. A reasonably good sensitivity, specificity, positive and negative predictive values were obtained in all types of leprosy except for mid borderline spectrum. FNAC is a simple, easy, cost effective, relatively non invasive procedure which provides faster results than biopsy. Drawbacks include- “dry taps”, bloody smears and lack of cellular infiltrate in case of macular lesions.en_US
dc.identifier.affiliationsGrace Swarupa Charles Baddam, MBBS, MD (DVL), Assistant Professor, Deptt. Of Dermatology & Venereology and Leprosy, Kamineni Institute of Medical Sciences, Narketpally, Telangana, 508254, Indiaen_US
dc.identifier.affiliationsVijay Praveen Sana, MBBS, MS (ENT) Assistant Professor, Deptt. of ENT, ESIC Medical College, Sanathnagar, Telangana, 500018, Indiaen_US
dc.identifier.affiliationsMadhavi Maddali, MBBS, MD (Path), DNB(Path), Fellow in Molecular Haematology, Senior Resident, Dept. of Haematology, Christian Medical College, Vellore, Tamil Nadu-632004, Indiaen_US
dc.identifier.affiliationsRamachandra S, MD (DVL), Retired Professor & HOD, Deptt. of Dermatology & Venereology and Leprosy Kamineni Institute of Medical Sciences, Narketpally, Telangana, 508254, Indiaen_US
dc.identifier.citationBaddam GSC, Sana VP, Maddali M, Ramachandra S. Validity of FNAC for the Diagnosis of Leprosy. Indian Journal of Leprosy. 2018 Jun; 90(2): 137-146en_US
dc.identifier.issn0254-9395
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/195005
dc.languageenen_US
dc.publisherHind Kusht Nivaran Sangh (Indian Leprosy Association)en_US
dc.relation.issuenumber2en_US
dc.relation.volume90en_US
dc.source.urihttps://www.ijl.org.in/apr-jun-2018.htmlen_US
dc.subjectLeprosyen_US
dc.subjectBiopsyen_US
dc.subjectAcid fast bacillien_US
dc.subjectFNACen_US
dc.titleValidity of FNAC for the Diagnosis of Leprosyen_US
dc.typeJournal Articleen_US
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