Rifampicin-associated intravascular haemolysis causing acute kidney injury
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Date
2025-04
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All India Institute of Medical Sciences
Abstract
Drug-induced acute kidney injury (AKI) is a rare adverse effect of rifampicin, and is mostly related to acute tubular necrosis and acute interstitial nephritis. We report a sputum- positive, isoniazid mono-resistant, pulmonary tuberculosis patient who had a history of anti-tuberculous therapy (ATT) intake 30 years ago. The patient developed AKI requiring dialysis when he restarted the ATT recently. A renal biopsy was consistent with pigment-cast nephropathy secondary to rifampicin-induced intravascular haemolysis. Rifampicin was stopped, and the patient underwent a total of four dialysis sessions and subsequently recovered.
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Aravindhmozhi P, Lamech TM, Swamikkannu C, Kurien AA, Gopalakrishnan N.. Rifampicin-associated intravascular haemolysis causing acute kidney injury. National Medical Journal of India. 2025 Apr; 38(2): 92-93