Effects of oral lithium on the action of various C.N.S. active drugs.

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dc.contributor.authorAwasthi, P Ken_US
dc.contributor.authorGarg, H Ken_US
dc.contributor.authorSrivastava, V Ken_US
dc.contributor.authorSinghal, K Cen_US
dc.contributor.authorChattaraj, Ten_US
dc.contributor.authorHasan, Men_US
dc.date.accessioned1996-07-01en_US
dc.date.accessioned2009-06-01T06:11:08Z
dc.date.available1996-07-01en_US
dc.date.available2009-06-01T06:11:08Z
dc.date.issued1996-07-01en_US
dc.description.abstractEffects of prolonged lithium administration was seen on the action of various psychoactive drugs in animals. Apomorphine induced pecking in pigeons increased significantly by lithium treatment for 14 days, from 1445.3 +/- 202.5 in control to 2785.8 +/- 205.8 in Gp. B. Haloperidol-induced catalepsy score in albino rats increased significantly following chronic lithium treatment compared to control. Chlorpromazine-induced hypothermia in rabbits was immediate but transient, while in lithium treated rabbits induction of hypothermia was delayed, sustained and of greater magnitude. This action of lithium may be mediated by increasing the permeability of blood-brain barrier, or enhancing the sensitivity of alpha-adrenoceptors in brain.en_US
dc.description.affiliationDepartment of Pharmacology, J.N. Medical College, A.M.U., Aligarh.en_US
dc.identifier.citationAwasthi PK, Garg HK, Srivastava VK, Singhal KC, Chattaraj T, Hasan M. Effects of oral lithium on the action of various C.N.S. active drugs. Indian Journal of Physiology and Pharmacology. 1996 Jul; 40(3): 241-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107190
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApomorphine --pharmacologyen_US
dc.subject.meshChlorpromazine --pharmacologyen_US
dc.subject.meshColumbidaeen_US
dc.subject.meshDrug Synergismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHaloperidol --pharmacologyen_US
dc.subject.meshLithium --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPsychotropic Drugs --pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshRatsen_US
dc.titleEffects of oral lithium on the action of various C.N.S. active drugs.en_US
dc.typeJournal Articleen_US
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