Microbial transformation of isonicotinic acid hydrazide and isonicotinic acid by Sarcina sp.
| dc.contributor.author | Gupta, R C | |
| dc.contributor.author | Shukla, O P | |
| dc.date.accessioned | 2015-07-17T11:03:08Z | |
| dc.date.available | 2015-07-17T11:03:08Z | |
| dc.date.issued | 1979-06 | |
| dc.description.abstract | Metabolism of isonicotinic acid and isoniazid by Sarcina sp. led to the formation of two metabolites which were characterised as 2-hydroxyisonicotinic acid and citrazinic acid. The blue pigment formed during fermentation was shown to be derived from the auto-oxidation of citrazinic acid. 2-Oxo-glutarate accumulated as the major keto acid when isonicotinic acid or isonicotinic acid hydrazide metabolism was inhibited by 1 mM sodium arsenite. Isonicotinic acid, 2-hydroxyisonicotinic acid and 2-oxo-glutarate were oxidised by isonicotinic acid hydrazide or isonicotinic acid-grown cells; citrazinic acid was, however, not oxidised. Isoniazid hydrazine hydrolase, isonicotinic acid and 2-hydroxyisonicotinic acid hydroxylases were detected in the cell-free extract of Sarcina sp. grown on isonicotinic acid hydrazide or isonicotinic acid. | en_US |
| dc.identifier.citation | Gupta R C, Shukla O P. Microbial transformation of isonicotinic acid hydrazide and isonicotinic acid by Sarcina sp. Journal of Biosciences. 1979 Jun; 1(2): 223-234. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/159967 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.ias.ac.in/jarch/jbiosci/1/223-234.pdf | en_US |
| dc.subject | Microbial transformation | en_US |
| dc.subject | isoniazid | en_US |
| dc.subject | isonicotinic acid | en_US |
| dc.subject | Sarcina | en_US |
| dc.title | Microbial transformation of isonicotinic acid hydrazide and isonicotinic acid by Sarcina sp. | en_US |
| dc.type | Article | en_US |