Comparative efficacy of IV phenytoin, IV valproate and IV levetiracetam in childhood seizures

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dc.contributor.authorDar, Sheeraz A.en_US
dc.contributor.authorWani, Wasim A.en_US
dc.contributor.authorNazir, Mudasiren_US
dc.contributor.authorHussan, Zul Eidainen_US
dc.date.accessioned2020-09-24T07:44:31Z
dc.date.available2020-09-24T07:44:31Z
dc.date.issued2019-07
dc.description.abstractBackground: Seizures are the most common pediatric neurologic disorder, with 4% to 10% of children suffering at least one seizure in the first 16 years of life objectives to compare efficacy of IV phenytoin, IV valproate, and IV levetiracetam in childhood seizures between 2months to 16 years of age.Methods: This prospective, randomized, study was done on pediatric patients in the age group of 2 months to 16 years who present actively convulsing to the emergency department of pediatrics.Results: At 24 hours seizures were controlled in 44 (88%) patients out of 50 patients in phenytoin group, 39 (78%) out of 50 patients in levetiracetam group and 46 (92%) out of 50 patients in valproate group (p-value 0.115). The relative risk of seizure recurrence for levetiracetam and phenytoin groups when compared to valproate was 2.75 and 1.5, respectively.Conclusions: Present study demonstrates that IV levetiracetam and IV valproate were comparable to IV phenytoin in terms of seizure control in acute setting. All the three are safe and efficacious. Time to regain consciousness was less in valproate group and long-term seizure control too was also better.en_US
dc.identifier.affiliationsDepartment of Pediatrics and Neonatology, Sher-I-Kashmir Institute of Medical Sciences Hospital, Srinagar, Jammu and Kashmir, Indiaen_US
dc.identifier.citationDar Sheeraz A., Wani Wasim A., Nazir Mudasir, Hussan Zul Eidain. Comparative efficacy of IV phenytoin, IV valproate and IV levetiracetam in childhood seizures. International Journal of Contemporary Pediatrics. 2019 Jul; 6(4): 1592-1597en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204144
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20192761en_US
dc.subjectChildhood seizuresen_US
dc.subjectLevetiracetamen_US
dc.subjectPhenytoinen_US
dc.subjectStatus epilepticusen_US
dc.subjectValproateen_US
dc.titleComparative efficacy of IV phenytoin, IV valproate and IV levetiracetam in childhood seizuresen_US
dc.typeJournal Articleen_US
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