Distribution of prognostically unfavourable product of c-erbB-2 oncogene and EGF-R in carcinomas of the breast and uterine cervix.

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dc.contributor.authorRay, Aen_US
dc.contributor.authorNaik, S L Den_US
dc.contributor.authorSharma, B Ken_US
dc.date.accessioned2002-10-10en_US
dc.date.accessioned2009-06-01T08:00:01Z
dc.date.available2002-10-10en_US
dc.date.available2009-06-01T08:00:01Z
dc.date.issued2002-10-10en_US
dc.description.abstractA comparative study was undertaken between cancer of the uterine cervix (n = 50) and female breast cancer (n = 50) with reference to the expression of c-erbB-2 oncoprotein (HER-2/neu) and that of epidermal growth factor receptor (EGF-R), both being highly homologous structurally. Expressions of EGF-R and c-erbB-2 oncoprotein were viewed in breast and cervical cancer tissues by immunochemical staining. Cervical cancer cases showed much higher expression of EGF-R which also revealed significant association with the expression of c-erbB-2 oncoprotein and tumour grading. Among breast cancer cases, over-expression of EGF-R correlated significantly with metastasis of lymph node; and expression of c-erbB-2 oncoprotein showed a significant relationship with histological grading of the tumour. Moreover, an association was noticed between the tumour grade and the concomitant immuno positive expression of EGF-R and c-erbB-2. Our study revealed an existence of a conflicting pattern in the expression of EGF-R and c-erbB-2 oncoprotein between carcinomas of the breast and uterine cervix.en_US
dc.description.affiliationInstitute of Cytology and Preventive Oncology (ICMR), Maulana Azad Medical College Campus, Bahadur Shah Zafar Marg, New Delhi-110 002.en_US
dc.identifier.citationRay A, Naik SL, Sharma BK. Distribution of prognostically unfavourable product of c-erbB-2 oncogene and EGF-R in carcinomas of the breast and uterine cervix. Indian Journal of Physiology and Pharmacology. 2002 Oct; 46(4): 423-33en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108582
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdulten_US
dc.subject.meshBreast Neoplasms --metabolismen_US
dc.subject.meshCarcinoma, Ductal, Breast --metabolismen_US
dc.subject.meshCarcinoma, Squamous Cell --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulation, Neoplastic --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReceptor, Epidermal Growth Factor --metabolismen_US
dc.subject.meshReceptor, erbB-2 --geneticsen_US
dc.subject.meshUterine Neoplasms --metabolismen_US
dc.titleDistribution of prognostically unfavourable product of c-erbB-2 oncogene and EGF-R in carcinomas of the breast and uterine cervix.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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