Sugammadex - A short review and clinical recommendations for the cardiac anesthesiologist.

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dc.contributor.authorHemmerling, Thomas M
dc.contributor.authorZaouter, Cedrick
dc.contributor.authorGeldner, Goetz
dc.contributor.authorNauheimer, Dirk
dc.date.accessioned2012-07-16T07:44:13Z
dc.date.available2012-07-16T07:44:13Z
dc.date.issued2010-09
dc.description.abstractThis review outlines the basic pharmacodynamic and pharmacokinetic properties of sugammadex for the cardiac anesthesiologist. It describes the different clinical scenarios when sugammadex can be used during cardiac surgery and gives clinical recommendations. Sugammadex is a unique reversal drug that binds a chemical complex with rocuronium and vecuronium, by which the neuromuscular blockade is quickly reversed. It is free of any clinical side-effects and doses of 2 mg/kg or more reliably reverse neuromuscular blockade within 5-15 min, depending on the depth of the neuromuscular blockade. Doses below 2 mg/kg should be avoided at any time because of the inherent risk of recurarization. Sugammadex should not replace good clinical practice - titration of neuromuscular blocking drugs to clinical needs and objective monitoring of neuromuscular blockade in the operating room or intensive care unit. Neuromuscular transmission should be determined in all patients before sugammadex is considered and 5 min after its administration to ensure that extubation is performed with normal neuromuscular transmission.en_US
dc.identifier.citationHemmerling Thomas M, Zaouter Cedrick, Geldner Goetz, Nauheimer Dirk. Sugammadex - A short review and clinical recommendations for the cardiac anesthesiologist. Annals of Cardiac Anaesthesia. 2010 Sept; 13(3): 206-216.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/139533
dc.language.isoenen_US
dc.source.urihttps://www.annals.in/article.asp?issn=0971-9784;year=2010;volume=13;issue=3;spage=206;epage=216;aulast=Hemmerlingen_US
dc.subjectCardiac surgeryen_US
dc.subjectreviewen_US
dc.subjectsugammadexen_US
dc.subject.meshAnesthesia
dc.subject.meshCardiac Surgical Procedures
dc.subject.meshClinical Trials as Topic
dc.subject.meshClinical Trials, Phase I as Topic
dc.subject.meshClinical Trials, Phase II as Topic
dc.subject.meshClinical Trials, Phase III as Topic
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshDrug Interactions
dc.subject.meshHumans
dc.subject.meshNeuromuscular Blockade
dc.subject.meshgamma-Cyclodextrins --adverse effects
dc.subject.meshgamma-Cyclodextrins --chemistry
dc.subject.meshgamma-Cyclodextrins --pharmacokinetics
dc.subject.othergamma-Cyclodextrins --pharmacology
dc.titleSugammadex - A short review and clinical recommendations for the cardiac anesthesiologist.en_US
dc.typeArticleen_US
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