Case report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies

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dc.contributor.authorBharathi-Devi, SRen_US
dc.contributor.authorCoral, Ken_US
dc.contributor.authorGayathree, Ken_US
dc.contributor.authorBharathselvi, Men_US
dc.contributor.authorSivasankar, Sen_US
dc.contributor.authorBiswas, Jen_US
dc.contributor.authorRishi, Pen_US
dc.contributor.authorNatarajan, Sen_US
dc.contributor.authorBadrinath, SSen_US
dc.contributor.authorAngayarkanni, Nen_US
dc.date.accessioned2020-04-10T02:04:57Z
dc.date.available2020-04-10T02:04:57Z
dc.date.issued2019-10
dc.description.abstractWe were intrigued to analyze donor eyes of two individuals without retinopathy even after 40 years of type 2 diabetes mellitus. Targeted molecular factors associated with angiogenesis and the key antioxidant enzymes in retinal tissue were analyzed. Accordingly PEDF, Adiponectin and Paraoxonase 2 showed augmented mRNA expression in both the retina with no significant change in VEGF expression. Vitreous showed increased PEDF protein in donor 1 and Adiponectin in donor 2 with no change in VEGF protein. This study highlights the profile of specific molecular factors that contribute to the non-development of diabetic retinopathy changes in these individuals.en_US
dc.identifier.affiliationsRS Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Chennai, Indiaen_US
dc.identifier.affiliationsDepartment of Uveitis, Medical Research Foundation, Chennai, Indiaen_US
dc.identifier.affiliationsShri Bhagwan Mahavir Vitreoretinal Services, Medical Research Foundation, Chennai, Indiaen_US
dc.identifier.affiliationsAditya Jyot Eye Hospital, Mumbai, Indiaen_US
dc.identifier.citationBharathi-Devi SR, Coral K, Gayathree K, Bharathselvi M, Sivasankar S, Biswas J, Rishi P, Natarajan S, Badrinath SS, Angayarkanni N. Case report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies. Indian Journal of Ophthalmology. 2019 Oct; 67(10): 1762-1765en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/197594
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber10en_US
dc.relation.volume67en_US
dc.source.urihttps://dx.doi.org/10.4103/ijo.IJO_400_19en_US
dc.subjectAdiponectin and paraoxonaseen_US
dc.subjectdiabetic retinopathyen_US
dc.subjectPEDFen_US
dc.subjectVEGFen_US
dc.titleCase report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studiesen_US
dc.typeJournal Articleen_US
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