The effect of lethal endotoxaemia on the liver glycogen metabolism in guineapigs with common bile duct obstruction.

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dc.contributor.authorEngin, Aen_US
dc.date.accessioned1995-09-01en_US
dc.date.accessioned2009-05-27T08:03:52Z
dc.date.available1995-09-01en_US
dc.date.available2009-05-27T08:03:52Z
dc.date.issued1995-09-01en_US
dc.description.abstractThe effect of hepatocellular trauma due to bile reflux and endotoxaemia on liver glycogen metabolism was studied in guineapigs with common bile duct obstruction. Considerable drops in basal glycogen levels of hepatocytes from bile duct ligated (BDL) animals were recorded in comparison with the sham operated (SHAM) ones. However, the regurgitation of bile did not affect the basal blood glucose concentrations of BDL guineapigs. The circulating glucose was consumed, mainly reflecting the level of energy requirement of the peripheral tissues in the endotoxaemic SHAM pair-fed animals and the BDL group. The hepatic glycogen stores failed to prevent the SHAM group from becoming hypoglycaemic at the end of the eighth hour after endotoxin administration. Enhancement in glucose consumption and diminished liver glycogen indicated the necessity of glucose intake in the early phase of extrahepatic bile duct obstruction. It was concluded that both endogenous and exogenous glucose have limited value in improving energy metabolism in lethal endotoxaemia following bile duct obstruction.en_US
dc.description.affiliationDepartment of General Surgery, School of Medicine Gazi University, Ankara, Turkey.en_US
dc.identifier.citationEngin A. The effect of lethal endotoxaemia on the liver glycogen metabolism in guineapigs with common bile duct obstruction. Indian Journal of Medical Research. 1995 Sep; 102(): 134-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/23106
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCholestasis --blooden_US
dc.subject.meshCommon Bile Duct Diseases --blooden_US
dc.subject.meshEndotoxins --blooden_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshLiver Glycogen --metabolismen_US
dc.subject.meshMaleen_US
dc.titleThe effect of lethal endotoxaemia on the liver glycogen metabolism in guineapigs with common bile duct obstruction.en_US
dc.typeJournal Articleen_US
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