Epidemiology and clinical spectrum of melioidosis: Analysis of cases from a tertiary care centre in southern Tamil Nadu

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dc.contributor.authorGanesan, Ven_US
dc.contributor.authorSundaramurthy, R.en_US
dc.date.accessioned2024-12-02T11:37:47Z
dc.date.available2024-12-02T11:37:47Z
dc.date.issued2024-01
dc.description.abstractBackground We studied the clinical features and treatment outcome of patients with melioidosis in our hospital. Methods We did this retrospective observational chart review over a period of 7 years between December 2014 and February 2022. Results There were 59 cases and 23 deaths attributable to melioidosis over the study period. The age range was 5 to 74 years and 48 (81.3%) were men. The comorbid conditions included diabetes mellitus (68%), alcoholism (11.8%), pulmonary tuberculosis (6.7%) and chronic kidney disease (5%). Over three-fourths of patients (78%) presented during the rainy season (June to December) and were acute presentations (44 [75%]). The most common sites were liver and spleen, followed by the musculoskeletal system, skin, soft tissues, lungs and brain. Of the 21 (36%) patients with septic shock, 16 (76%) died. On the contrary, of 38 (64%) patients without septic shock, only 11% died. Of the 27 (47%) admitted to ICU, 11 (41%) died. In ICU, 18 (67%) were ventilated. Of the 23 (39%) deaths overall, median time from admission to death was 4 days. There were no relapses in the 42% patients followed up for 2–6 months. Conclusions The epidemiology of melioidosis is similar to other endemic areas with preponderance of men. There was a temporal association with the monsoon season and a higher number of acute cases. The differences included a higher proportion of deep visceral abscesses and musculo-skeletal involvement compared to lung involvement.en_US
dc.identifier.affiliationsDepartment of Microbiology, Velammal Medical College Hospital and Research Institute, Madurai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, All India Institute of Medical Sciences, Bibinagar, Hyderabad 508126, Telengana, Indiaen_US
dc.identifier.citationGanesan V, Sundaramurthy R.. Epidemiology and clinical spectrum of melioidosis: Analysis of cases from a tertiary care centre in southern Tamil Nadu. National Medical Journal of India. 2024 Jan; 37(1): 22-25en_US
dc.identifier.issn0970-258X
dc.identifier.issn2583-150X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/240477
dc.languageenen_US
dc.publisherAll India Institute of Medical Sciencesen_US
dc.relation.issuenumber1en_US
dc.relation.volume37en_US
dc.source.urihttps://dx.doi.org/10.25259/NMJI_402_2022en_US
dc.titleEpidemiology and clinical spectrum of melioidosis: Analysis of cases from a tertiary care centre in southern Tamil Naduen_US
dc.typeJournal Articleen_US
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