A simplified in vivo drug sensitivity test for malaria in the field.

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dc.contributor.authorLwin, Men_US
dc.contributor.authorAung, Sen_US
dc.contributor.authorKyaw, M Pen_US
dc.contributor.authorAung, Hen_US
dc.contributor.authorSint, Nen_US
dc.contributor.authorWin, Yen_US
dc.contributor.authorOo, Hen_US
dc.contributor.authorThein, Hen_US
dc.contributor.authorTun, S Men_US
dc.date.accessioned2009-05-27T15:53:49Z
dc.date.available2009-05-27T15:53:49Z
dc.date.issued1997-06-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe study was intended to develop a simple and reliable in vivo field test for monitoring of sensitivity of P.falciparum to antimalarials. The test is to be used as a built in sustainable monitoring system and applied at regular frequencies to provide guidance in developing a country-wide antimalarial drug policy. The study was conducted as a hospital based study in Mon State in Mudon, Kamawet and Pa-auk hospitals. The criteria matched malaria patients were treated with standard dosages of chloroquine, sulfadoxine-pyrimethamine and mefloquine and blood films were taken on days 0, 2, 3, 4, 7, 14 and 28. The assessment of the in vivo drug response of P.falciparum on days 2, 3 and 4 were compared with WHO standard 28 days and 7 day tests. The following successful tests were carried out for 7 days with different antimalarials: 171 tests with chloroquine and sulfadoxine-pyrimethamine and 167 tests with mefloquine. Tests were also carried out for 28 days: 59 tests with chloroquine, 77 tests with sulfadoxine-pyrimethamine and 78 tests with mefloquine. The results found that 3 day tests, taking blood films on days 0 and 3, can be reliably used as an adjunct to 28-day tests. Since the test is simple and can be used extensively and sustainably throughout the country and the results are applicable to be used for epidemiological purposes, the method is suggested for use as a built-in monitoring method for the malaria control program.en_US
dc.description.affiliationDepartment of Medical Research, Ministry of Health, Yangon, Myanmar.en_US
dc.identifier.citationLwin M, Aung S, Kyaw MP, Aung H, Sint N, Win Y, Oo H, Thein H, Tun SM. A simplified in vivo drug sensitivity test for malaria in the field. The Southeast Asian Journal of Tropical Medicine and Public Health. 1997 Jun; 28(2): 247-53en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/33927
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntimalarials --pharmacologyen_US
dc.subject.meshChilden_US
dc.subject.meshChloroquine --pharmacologyen_US
dc.subject.meshDrug Combinationsen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMalaria, Falciparum --diagnosisen_US
dc.subject.meshMaleen_US
dc.subject.meshMefloquine --pharmacologyen_US
dc.subject.meshMyanmar --epidemiologyen_US
dc.subject.meshPlasmodium falciparum --drug effectsen_US
dc.subject.meshPyrimethamine --pharmacologyen_US
dc.subject.meshSulfadoxine --pharmacologyen_US
dc.subject.meshTime Factorsen_US
dc.titleA simplified in vivo drug sensitivity test for malaria in the field.en_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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