Detection of Microhemorrhages in Cerebral Amyloid Angiopathy by Susceptibility Weighted MR Imaging – An Observational Study

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dc.contributor.authorSingh, Mamataen_US
dc.contributor.authorRautray, Prabhat Nalinien_US
dc.contributor.authorGantayet, Mayaen_US
dc.date.accessioned2020-09-24T07:10:30Z
dc.date.available2020-09-24T07:10:30Z
dc.date.issued2019-08
dc.description.abstractIntroduction: Cerebral amyloid angiopathy (CAA) is acause for approximately 10-20% of spontaneous intracerebralhaemorrhage in elderly population. Susceptibility weightedimaging (SW1) is a new imaging method is clinically usefulfor evaluating the presence of chronic blood products in thebrain, especially clinically silent microbleeds associatedwith cerebral amyloid angiopathy. Aim of this study was todetermine the advantages of Susceptibility weighted imaging(SW1) over conventional gradient echo (GRE) technique in aprobable diagnosis of Cerebral amyloid angiopathy.Material and Methods: All patients more than 55 yrspresented with neurological signs and symptoms referredfor neuroimaging, were subjected to image with MRI usingT1W, T2W, FLAIR. AXIAL 2D MERGE, Diffusion weightedimaging (DWI) including apparent diffusion coefficient(ADC) and Susceptibility weighted imaging (SWI). Thosecases having multiple macro and micro haemorrhagesinvolving cortical and sub cortical region detected by eithergradient or SWI included in the study.Results: Sudden onset of neurological deficit was the mostcommon symptom which accounted for 37% of cases.Cortical and sub cortical regions are most commonly involvedsites. On comparison between gradient and SWI, 11 caseshaving micro hemorrgages detected only by SWI and absentin gradient.Conclusion: GE - T2* MR imaging is currently the “ standard”for identifying microhemorrhages and diagnosing cerebralamyloid angiopathy based on number and distribution of microhaemorrhages. SW1 identified many more microhemorrhagesthan conventional T2* weighted GE magnitude technique andmay lead to earlier diagnosis of patients with CAA.en_US
dc.identifier.affiliationsAssistant Professor, Department of Radiodiagnosis , SCB MC&H, Cuttacken_US
dc.identifier.affiliationsAssistant Professor, Department of Radiodiagnosis , PRM MC&H, Baripadaen_US
dc.identifier.affiliationsChief Consultant, Department of Neuology, Ashwini Neuro-centre, Cuttack, Indiaen_US
dc.identifier.citationSingh Mamata, Rautray Prabhat Nalini, Gantayet Maya. Detection of Microhemorrhages in Cerebral Amyloid Angiopathy by Susceptibility Weighted MR Imaging – An Observational Study. International Journal of Contemporary Medical Research . 2019 Aug; 6(8): h1-h5en_US
dc.identifier.issn2393-915X
dc.identifier.issn2454-7379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/202520
dc.languageenen_US
dc.publisherInternational Society for Contemporary Medical Researchen_US
dc.relation.issuenumber8en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.21276/ijcmr.2019.6.8.6en_US
dc.subjectDementiaen_US
dc.subjectCerebral Haemorrhageen_US
dc.subjectCortical and Subcortical.en_US
dc.titleDetection of Microhemorrhages in Cerebral Amyloid Angiopathy by Susceptibility Weighted MR Imaging – An Observational Studyen_US
dc.typeJournal Articleen_US
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