Allium Cepa Root Chromosomal Aberration Assay: A Review.
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Date
2013-07
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Abstract
Higher plants, an important material for genetic tests to monitor various pollutant present in the environment.
Among the plant species, Alium cepa has been used to evaluate chromosome aberrations and disturbances in the
mitotic cycle. Now days, it has been used to assess a great number of genotoxic/antigenotoxic agents, which
contributes to its increasing application in environmental monitoring. The A. cepa is commonly used as a test
organism because it is cheap, easily available and handled and has advantages over other short-term tests. Among
the endpoints of A. cepa root chromosomal aberrations, detection of chromosomal aberration have been the most
used one to detect genotoxicity/ antigenotoxicity along the years. The mitotic index and chromosomal abnormalities
are used to evaluate genotoxicity and micronucleus analysis used to verify mutagenicity of different chemicals. The
Allium cepa root chromosomal aberration assay is widely used to determine genotoxic and antigenotoxic effects of
different plant extracts.
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Keywords
Allium cepa, genotoxicity, clastogenic, mitotic index
Citation
Khanna Namita, Sharma Sonia. Allium Cepa Root Chromosomal Aberration Assay: A Review. Indian Journal of Pharmaceutical & Biological Research. 2013 Jul-Sept; 1 (3): 105-119.