Enhancement of Solubility And Dissolution Profile of Clopidogrel By Various Solid Dispersion Formulations

Simple item page
dc.contributor.authorKhader, M. A.en_US
dc.contributor.authorSalfi, R.en_US
dc.date.accessioned2020-10-16T07:51:22Z
dc.date.available2020-10-16T07:51:22Z
dc.date.issued2020-07
dc.description.abstractThe present research is aimed at enhancing solubility and drug dissolution of clopidogrel (CPG) used as oral antiplatelet agent by employing solid dispersion (SD) technique. Total 40 SDs formulated with drug: polymers (pluronic F127, poloxamer 407, labrafil PG, PEG 6000, gelucire 50/13), in varying ratios (1:0.5, 1:1, 1:2, 1:3, 1:4) of which CPG1 to CPG20 and CPG21 to CPG40 prepared by adopting solvent evaporation method fusion (melt) method respectively. The formulation CPG40 containing pluronic F127 as polymer showed highest solubility of 6.57±0.04 mg/ml) that is 45 folds than pure drug. Similar results reflected in the dissolution studies where CPG40 containing CPG: pluronic F127 in 1:4 ratio showed maximum % drug content, % practical yield and drug dissolution of 99.14% in 60 minutes when compared with other formulations and pure drug (32.76%) obtained by fusion melt method. From FTIR studies the optimized formulation CPG40 showed the compatibility between drug and polymers. XRD and SEM studies showed CPG40 exists in amorphous form that fetched in better drug release from the SD formulation in comparison to pure drug.en_US
dc.identifier.affiliationsDepartment of Pharmacy, Mewar University, Chittorgarh-312901, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacy, Mewar University, Chittorgarh-312901, Rajasthan, Indiaen_US
dc.identifier.citationKhader M. A., Salfi R.. Enhancement of Solubility And Dissolution Profile of Clopidogrel By Various Solid Dispersion Formulations. International Journal of Pharmaceutical Sciences and Drug Research. 2020 Jul; 12(4): 377-383en_US
dc.identifier.issn0975-248X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206335
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber4en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.25004/IJPSDR.2020.120410en_US
dc.subjectClopidogrelen_US
dc.subjectsolid dispersionen_US
dc.subjectfusion (melt) methoden_US
dc.subjectpluronic F127en_US
dc.subjectplatelet aggregation inhibitoren_US
dc.titleEnhancement of Solubility And Dissolution Profile of Clopidogrel By Various Solid Dispersion Formulationsen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijpsdr2020v12n4p377.pdf
Size:
1.35 MB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Pharmaceutical Sciences and Drug Research